Evidence map›Paper›PMID 39447095›Full record

ArticleJCO precision oncology2024

Multiomic Characterization and Molecular Profiling of Nuclear Protein in Testis Carcinoma.

Gianna Kroening, Jia Luo, Mark G Evans, Tolulope Adeyelu, Sai-Hong Ignatius Ou, Zhaohui L Arter, Trisha M Wise-Draper, Ammar Sukari, Asfar S Azmi, David R Braxton and 7 more

Abstract read
In one paragraph

Article in JCO precision oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Molecular Characterization of NUT Carcinoma: A Report from the NUT Carcinoma Registry.Clinical cancer research : an official journal of the American Association for Cancer Research · 2025
    Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Gianna KroeningUniversity of California Irvine School of Medicine, Orange, CA.ORCID 0000-0002-9885-2986
Jia LuoDana-Farber Cancer Institute, Boston, MA.ORCID 0000-0003-3606-827X
Mark G EvansCaris Life Sciences, Phoenix, AZ.ORCID 0000-0001-9358-9843
Tolulope AdeyeluCaris Life Sciences, Phoenix, AZ.
Sai-Hong Ignatius OuUniversity of California Irvine School of Medicine, Orange, CA.ORCID 0000-0002-1764-4975
Zhaohui L ArterUniversity of California Irvine School of Medicine, Orange, CA.ORCID 0000-0001-7394-7156
Trisha M Wise-DraperUniversity of Cincinnati, Cincinnati, OH.ORCID 0000-0002-7279-4028
Ammar SukariKarmanos Cancer Institute, Detroit, MI.
Asfar S AzmiKarmanos Cancer Institute, Detroit, MI.ORCID 0000-0002-1008-1807
David R BraxtonHoag Family Cancer Institute, Newport Beach, CA.ORCID 0000-0003-2559-2578
Andrew ElliottCaris Life Sciences, Phoenix, AZ.
David A BryantCaris Life Sciences, Phoenix, AZ.
Matthew J OberleyCaris Life Sciences, Phoenix, AZ.ORCID 0000-0001-6419-2513
Chul KimLombardi Comprehensive Cancer Center, Georgetown University, Washington, DC.ORCID 0000-0003-0191-8684
Geoffrey I ShapiroDana-Farber Cancer Institute, Boston, MA.ORCID 0000-0002-3331-4095
Christopher A FrenchBrigham and Women's Hospital and Harvard Medical School, Boston, MA.ORCID 0000-0002-7434-4987
Misako NagasakaUniversity of California Irvine School of Medicine, Orange, CA.ORCID 0000-0001-5308-615X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeNuclear protein in testis carcinoma (NC) is an underdiagnosed and aggressive squamous/poorly differentiated cancer characterized by rearrangement of the gene

methodsWe analyzed the genomic and immune landscape of 54 cases of NC that underwent DNA- and RNA-based NGS sequencing (Caris).

resultsWhile NC is driven by

conclusionTo our knowledge, this is the first series of NC profiled broadly at the DNA and RNA level. We observed fewer intratumoral immune cells by RNA sequencing, which may be associated with anecdotal data of lack of immunotherapy benefit in NC. High

Indexed as

Nuclear ProteinsAdultAgedFemaleHumansMaleMiddle AgedNeoplasm ProteinsNeoplasm ProteinsNuclear ProteinsNUTM1 protein, human

Identifiers

PMID39447095
PMCPMC11520346

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.