ArticleScience (New York, N.Y.)2024
Dietary pro-oxidant therapy by a vitamin K precursor targets PI 3-kinase VPS34 function.
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Article in Science (New York, N.Y.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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35citing papers in PubMed
–field-weighted citation impact
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Who cites it
35 citing papers in PubMed.
- Spatiotemporal dynamics of the host-tumor metabolic interface: Implications for precision nutritional oncology.Genes & diseases · 2026Review
- Beyond the canon: emerging modalities of regulated cell death.Cell death and differentiation · 2026Article
- Metabolites and cancer metastasis.Oncogene · 2026Review
- Exploration and experimental verification of triaptosis-related prognostic genes and cells in gastric cancer.Molecular biology reports · 2026Article
- Ascorbate-driven quinone redox cycling as a pro-oxidant anticancer strategy.Redox biology · 2026Review
- When vitamins decide life or death.Cell death and differentiation · 2026Article
- A multienzyme-mimicking nanoplatform induces disulfidptosis/cuproptosis/apoptosis for tumor therapy.National science review · 2026Article
- Metabolic rewiring driven by phosphoglycolate phosphatase deletion inhibits ferroptosis.Science advances · 2026Article
- Cell death pathways and targeting therapeutics in cancer therapy.Acta pharmacologica Sinica · 2026Review
- Integrating single-cell multi-omics and machine learning to reveal triaptosis heterogeneity in clear cell renal cell carcinoma.Human genomics · 2026Article
- Targeting non-apoptotic regulated cell death (RCD) to treat neurodegenerative diseases.Acta pharmaceutica Sinica. B · 2026Review
- Immune Checkpoint Inhibitors and Immunomodulators for Cancer Immunotherapy: Insights Into Resistance and Therapeutic Strategies.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Tumour promotion through the lens of evolution.Nature · 2026Review
- The Role of Gut Microbiome in Prostate Cancer: Current Evidence and Emerging Opportunities.Cancers · 2026Review
- A novel triaptosis-related prognostic signature to assess the clinical value in HER2-low breast cancer: evidence from clinical cohorts and experimental validation.Apoptosis : an international journal on programmed cell death · 2026Article
- Vitamin A and its analogues modulate MUFAs metabolism to improve ferroptosis and aging by direct targeting of ACSL3.Acta pharmaceutica Sinica. B · 2026Article
- Editorial: Ferroptosis, cuproptosis, and triaptosis: unveiling pathways and translational prospects.Frontiers in cell and developmental biology · 2026Article
- In Vitro Effects of Cabazitaxel and Menadione on Cell Growth, Metabolism, and Transcriptomic Profile of Human Prostate Cancer Cell Lines.Prostate cancer · 2026Article
- Vitamin K and muscle health: mechanisms and clinical perspectives in sarcopenia and beyond: narrative review.Frontiers in nutrition · 2026Review
- Exploiting Oxidative Stress as Achilles' Heel: From Redox Homeostasis to Ferroptosis in Prostate Cancer.Antioxidants (Basel, Switzerland) · 2025Review
Corrections and comments
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Authors and funding
45 authors.
Manojit M SwamynathanCold Spring Harbor Laboratory, Cold Spring Harbor, NY 11771, USA.ORCID 0000-0003-1156-586X
Shan Kuang *Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11771, USA.
Kaitlin E Watrud *Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11771, USA.
Mary R Doherty *Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11771, USA.
Charlotte GinesteInstitut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS UMR7104, Inserm U1258, Strasbourg University, Illkirch CEDEX 67404, France.ORCID 0000-0001-8515-089X
Grinu MathewCold Spring Harbor Laboratory, Cold Spring Harbor, NY 11771, USA.ORCID 0000-0001-6115-6373
Grace Q GongMRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK.ORCID 0000-0002-7609-0466
Hilary CoxCold Spring Harbor Laboratory, Cold Spring Harbor, NY 11771, USA.ORCID 0009-0000-4652-393X
Eileen ChengCold Spring Harbor Laboratory, Cold Spring Harbor, NY 11771, USA.ORCID 0009-0004-3308-8704
David ReissInstitut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS UMR7104, Inserm U1258, Strasbourg University, Illkirch CEDEX 67404, France.
Jude KendallCold Spring Harbor Laboratory, Cold Spring Harbor, NY 11771, USA.
Diya GhoshCold Spring Harbor Laboratory, Cold Spring Harbor, NY 11771, USA.ORCID 0009-0006-7849-1614
Colleen R ReczekDepartment of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.ORCID 0000-0002-9106-5912
Xiang ZhaoCold Spring Harbor Laboratory, Cold Spring Harbor, NY 11771, USA.ORCID 0000-0003-3067-3970
Tali HerzkaCold Spring Harbor Laboratory, Cold Spring Harbor, NY 11771, USA.
Saulė ŠpokaitėMRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK.ORCID 0000-0001-9461-7957
Antoine N DessusMRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK.ORCID 0009-0003-2517-0188
Seung Tea KimCold Spring Harbor Laboratory, Cold Spring Harbor, NY 11771, USA.ORCID 0000-0002-1004-9292
Olaf KlingbeilCold Spring Harbor Laboratory, Cold Spring Harbor, NY 11771, USA.
Juan LiuDepartment of Molecular and Structural Biochemistry, North Carolina State University, Raleigh, NC 27695, USA.
Dawid G NowakDepartment of Medicine, Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10065, USA.ORCID 0000-0003-4910-8963
Habeeb AlsudaniCold Spring Harbor Laboratory, Cold Spring Harbor, NY 11771, USA.
Tse-Luen WeeCold Spring Harbor Laboratory, Cold Spring Harbor, NY 11771, USA.ORCID 0000-0002-4141-3157
Youngkyu ParkCold Spring Harbor Laboratory, Cold Spring Harbor, NY 11771, USA.ORCID 0000-0003-1169-6739
Francesca MinicozziCold Spring Harbor Laboratory, Cold Spring Harbor, NY 11771, USA.ORCID 0009-0007-7910-3342
Keith RiveraCold Spring Harbor Laboratory, Cold Spring Harbor, NY 11771, USA.ORCID 0000-0003-2979-9576
Ana S AlmeidaCold Spring Harbor Laboratory, Cold Spring Harbor, NY 11771, USA.ORCID 0000-0001-8997-2639
Kenneth ChangCold Spring Harbor Laboratory, Cold Spring Harbor, NY 11771, USA.ORCID 0000-0002-5833-3655
Ram P ChakrabartyDepartment of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.ORCID 0000-0002-5425-6306
John E WilkinsonDepartment of Pathology, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0001-9174-8556
Phyllis A GimottyPerelman School of Medicine, Division of Biostatistics, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0002-3850-9799
Sarah D DiermeierDepartment of Biochemistry, University of Otago, Dunedin 9016, New Zealand.ORCID 0000-0002-6120-2744
Mikala EgebladCold Spring Harbor Laboratory, Cold Spring Harbor, NY 11771, USA.ORCID 0000-0002-3371-1445
Christopher R VakocCold Spring Harbor Laboratory, Cold Spring Harbor, NY 11771, USA.
Jason W LocasaleDepartment of Molecular and Structural Biochemistry, North Carolina State University, Raleigh, NC 27695, USA.ORCID 0000-0002-7766-3502
Navdeep S ChandelDepartment of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.ORCID 0000-0001-7208-3886
Tobias JanowitzCold Spring Harbor Laboratory, Cold Spring Harbor, NY 11771, USA.ORCID 0000-0002-7820-3727
James B HicksCold Spring Harbor Laboratory, Cold Spring Harbor, NY 11771, USA.
Michael WiglerCold Spring Harbor Laboratory, Cold Spring Harbor, NY 11771, USA.ORCID 0000-0003-4396-1971
Darryl J PappinCold Spring Harbor Laboratory, Cold Spring Harbor, NY 11771, USA.ORCID 0000-0002-8981-8401
Roger L WilliamsMRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK.ORCID 0000-0001-7754-4207
Paolo CifaniCold Spring Harbor Laboratory, Cold Spring Harbor, NY 11771, USA.ORCID 0000-0002-4403-1277
David A TuvesonCold Spring Harbor Laboratory, Cold Spring Harbor, NY 11771, USA.ORCID 0000-0002-8017-2712
Jocelyn LaporteInstitut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS UMR7104, Inserm U1258, Strasbourg University, Illkirch CEDEX 67404, France.ORCID 0000-0001-8256-5862
Lloyd C TrotmanCold Spring Harbor Laboratory, Cold Spring Harbor, NY 11771, USA.ORCID 0000-0002-4794-1559
Funding
Single-Cell Biology Shared ResourceP30CA045508 · NCI · COLD SPRING HARBOR LABORATORY · PI John Edward Moses · 1987 to 2026
$118.9MPancreatic Cancer Detection ConsortiumU01CA210240 · NCI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI Michael A. Hollingsworth · 2017 to 2026
$12.9MCSHL-JAX Patient-Derived Models of Pancreatic Cancer as Systems for Investigating Tumor HeterogeneityU01CA224013 · NCI · COLD SPRING HARBOR LABORATORY · PI ROBSON, PAUL, TUVESON, DAVID A · 2018 to 2022
$4.2MTargeting aberrant enhancer landscapes in pancreatic cancerR01CA229699 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI Christopher Vakoc · 2019 to 2026
$3.3MDietary methionine and cancerR01CA193256 · NCI · DUKE UNIVERSITY · PI LOCASALE, JASON W. · 2015 to 2023
$3.1MMechanisms and Treatment of PTEN Mutant Prostate TumorigenesisR01CA137050 · NCI · COLD SPRING HARBOR LABORATORY · PI TROTMAN, LLOYD C · 2010 to 2018
$3.1MNrf2 Regulation of Ductal Pancreatic Cancer Etiology and Treatment ResponseR01CA188134 · NCI · COLD SPRING HARBOR LABORATORY · PI TUVESON, DAVID A · 2017 to 2021
$3.0MMetastasis of PTEN Mutant Prostate CancerR01CA275128 · NCI · COLD SPRING HARBOR LABORATORY · PI TROTMAN, LLOYD C · 2022 to 2025
$2.7M(PQA-4) Organoid Omics To Detect And Defeat Ductal Pancreatic CancerR01CA190092 · NCI · COLD SPRING HARBOR LABORATORY · PI TUVESON, DAVID A · 2014 to 2017
$2.2MPreclinical Models for Cancer Therapeutic DevelopmentR50CA211506 · NCI · COLD SPRING HARBOR LABORATORY · PI PARK, YOUNGKYU · 2016 to 2025
$2.1MNCI NIH HHS P30 CA045508NCI NIH HHS R01 CA137050NCI NIH HHS R01 CA188134NCI NIH HHS R01 CA190092NCI NIH HHS R01 CA193256NCI NIH HHS R01 CA229699NCI NIH HHS R01 CA275128NCI NIH HHS R50 CA211506NCI NIH HHS U01 CA210240NCI NIH HHS U01 CA224013
Abstract
Men taking antioxidant vitamin E supplements have increased prostate cancer (PC) risk. However, whether pro-oxidants protect from PC remained unclear. In this work, we show that a pro-oxidant vitamin K precursor [menadione sodium bisulfite (MSB)] suppresses PC progression in mice, killing cells through an oxidative cell death: MSB antagonizes the essential class III phosphatidylinositol (PI) 3-kinase VPS34-the regulator of endosome identity and sorting-through oxidation of key cysteines, pointing to a redox checkpoint in sorting. Testing MSB in a myotubular myopathy model that is driven by loss of
Indexed as
Class III Phosphatidylinositol 3-KinasesMuscular DiseasesOxidantsProstatic NeoplasmsVitamin K 3AnimalsCysteineDietary SupplementsHumansLongevityMaleMiceOxidation-ReductionProtein Tyrosine Phosphatases, Non-ReceptorClass III Phosphatidylinositol 3-KinasesCysteineOxidantsPIK3C3 protein, mouseProtein Tyrosine Phosphatases, Non-ReceptorVitamin K 3
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