Evidence map›Paper›PMID 39446705›Full record

ArticleChemistry & biodiversity2025

Analysis of Chemical Composition, Antioxidant Capacity, Acute Toxicity, and Antinociceptive Properties of Aqueous Extract of Origanum Majorana L.

My Ahmed El Amiri, Hamid Kabdy, Abdelfatah Aitbaba, Jawad Laadraoui, Rachida Aboufatima, Loubna El Yazouli, Baslam Abdelmounaim, Soad Moubtakir, Stefania Garzoli, Chait Abderrahman

Abstract read
In one paragraph

Article in Chemistry & biodiversity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. GC-MS profiling,Frontiers in chemistry · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

My Ahmed El AmiriLaboratory of biochemistry, Faculty of medicine and pharmacy, University Cadi Ayyad, Marrakech, Morocco.
Hamid KabdyLaboratory of Pharmacology, Neurobiology and Behavior, Faculty of Sciences Semlalia, University Cadi Ayyad, Marrakech, Morocco.
Abdelfatah AitbabaLaboratory of Pharmacology, Neurobiology and Behavior, Faculty of Sciences Semlalia, University Cadi Ayyad, Marrakech, Morocco.
Jawad LaadraouiLaboratory of Physiopathology, Genetic Molecular and Biotechnology, Faculty of Sciences, Aïn Chock, Hassan II University, Casablanca, Morocco.
Rachida AboufatimaLaboratory of Biological Engineering, Faculty of Sciences and Technology, Sultan Moulay Slimane University, Beni Mellal, 23000, Morocco.
Loubna El YazouliLaboratory of Pharmacology, Neurobiology and Behavior, Faculty of Sciences Semlalia, University Cadi Ayyad, Marrakech, Morocco.
Baslam AbdelmounaimLaboratory of Pharmacology, Neurobiology and Behavior, Faculty of Sciences Semlalia, University Cadi Ayyad, Marrakech, Morocco.
Soad MoubtakirLaboratory of Pharmacology, Neurobiology and Behavior, Faculty of Sciences Semlalia, University Cadi Ayyad, Marrakech, Morocco.
Stefania GarzoliDepartment of Chemistry and Technologies of Drug, Sapienza University, P. le Aldo Moro, 500185, Rome, Italy.ORCID https://orcid.org/0000-0001-8535-0533
Chait AbderrahmanLaboratory of Pharmacology, Neurobiology and Behavior, Faculty of Sciences Semlalia, University Cadi Ayyad, Marrakech, Morocco.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pharmacological evaluation showed that AEOM significantly reduced pain in an animal model, suggesting potential analgesic properties. Acute toxicity studies indicated no adverse effects on kidney and liver function or blood parameters at doses up to 800 mg/kg. The analgesic effect is likely mediated by flavonoids in the extract, which may inhibit pain pathways. These findings suggest that O. majorana has promising therapeutic applications, particularly as a natural analgesic agent.

Indexed as

AnalgesicsAntioxidantsOriganumPlant ExtractsAnimalsDose-Response Relationship, DrugFlavonoidsMaleMicePainToxicity Tests, AcuteWaterAnalgesicsAntioxidantsFlavonoidsPlant ExtractsWaterAntinociceptiveAntioxidantOriganum majorana LPhytochemical compositionToxicity

Identifiers

PMID39446705
PMCPMC11908776

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.