Evidence map›Paper›PMID 39446574›Full record

ArticleAngewandte Chemie (International ed. in English)2024

Chaperone-Derived Copper(I)-Binding Peptide Nanofibers Disrupt Copper Homeostasis in Cancer Cells.

M T Jeena, Julian Link, Jian Zhang, Iain Harley, Petri Turunen, Robert Graf, Manfred Wagner, Luis Andre Baptista, Hendrik R A Jonker, Liyang Cui and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Carrier-free GSH-responsiveMaterials today. Bio · 2026
    Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

M T JeenaMax-Planck-Institut für Polymerforschung, Ackermannweg 10, 55128, Mainz, Germany.
Julian LinkMax-Planck-Institut für Polymerforschung, Ackermannweg 10, 55128, Mainz, Germany.
Jian ZhangMax-Planck-Institut für Polymerforschung, Ackermannweg 10, 55128, Mainz, Germany.
Iain HarleyMax-Planck-Institut für Polymerforschung, Ackermannweg 10, 55128, Mainz, Germany.
Petri TurunenZentrale Einrichtung für Mikroskopie, Institut für Molekulare Biologie (IMB), Johannes Gutenberg-Universität, Ackermannweg 4, 55128, Mainz, Germany.
Robert GrafMax-Planck-Institut für Polymerforschung, Ackermannweg 10, 55128, Mainz, Germany.
Manfred WagnerMax-Planck-Institut für Polymerforschung, Ackermannweg 10, 55128, Mainz, Germany.
Luis Andre BaptistaMax-Planck-Institut für Polymerforschung, Ackermannweg 10, 55128, Mainz, Germany.
Hendrik R A JonkerInstitut für Organische Chemie und Chemische Biologie, Biomolekulares Magnetresonanz Zentrum (BMRZ), Goethe Universität Frankfurt, 60438, Frankfurt am Main, Germany.
Liyang CuiDepartment of Radiology, Molecular Imaging Program at Stanford, School of Medicine, Stanford University, Stanford, CA, 94305, USA.
Ingo LieberwirthMax-Planck-Institut für Polymerforschung, Ackermannweg 10, 55128, Mainz, Germany.
Katharina LandfesterMax-Planck-Institut für Polymerforschung, Ackermannweg 10, 55128, Mainz, Germany.
Jianghong RaoDepartment of Radiology, Molecular Imaging Program at Stanford, School of Medicine, Stanford University, Stanford, CA, 94305, USA.
David Y W NgMax-Planck-Institut für Polymerforschung, Ackermannweg 10, 55128, Mainz, Germany.
Tanja WeilMax-Planck-Institut für Polymerforschung, Ackermannweg 10, 55128, Mainz, Germany.ORCID 0000-0002-5906-7205

Funding

Copper-depleting nanotheranostics for treating triple negative breast cancerR01CA243033 · NCI · STANFORD UNIVERSITY · PI RAO, JIANGHONG · 2019 to 2023
$3.0M
Alexander von Humboldt-StiftungH2020 Marie Skłodowska-Curie Actions 860914NCI NIH HHS R01CA24303NCI NIH HHS R01 CA243033
6 · The paper itself

Abstract

Copper (Cu) is a transition metal that plays crucial roles in cellular metabolism. Cu

Indexed as

CopperHomeostasisMolecular ChaperonesNanofibersPeptidesAntineoplastic AgentsCell Line, TumorHumansAntineoplastic AgentsCopperMolecular ChaperonesPeptidesCancer therapeuticsCu+ homeostasis interruptionIntracellular self-assemblyOxidative stress

Identifiers

PMID39446574
PMCPMC11627128

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.