Evidence map›Paper›PMID 39446280›Full record

ArticleMedical & biological engineering & computing2025

Comprehensive validation of a compact laser speckle contrast imaging system for vascular function assessment: from the laboratory to the clinic.

Meng-Che Hsieh, Chia-Yu Chang, Ching-Han Hsu, Congo Tak Shing Ching, Lun-De Liao

Abstract readValidation Study
PubMed Publisher
In one paragraph

Article in Medical & biological engineering & computing, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Meng-Che HsiehInstitute of Biomedical Engineering and Nanomedicine, National Health Research Institutes, 35, Keyan Road, Zhunan Town, Miaoli County, 35053, Taiwan.
Chia-Yu ChangInstitute of Biomedical Engineering and Nanomedicine, National Health Research Institutes, 35, Keyan Road, Zhunan Town, Miaoli County, 35053, Taiwan.
Ching-Han HsuDepartment of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, No. 101, Section 2, Kuang-Fu Road, Hsinchu, 30013, Taiwan.
Congo Tak Shing ChingDoctoral Program in Tissue Engineering and Regenerative Medicine, National Chung Hsing University, 145, Xingda Road, South District, Taichung City, 402, Taiwan.
Lun-De LiaoInstitute of Biomedical Engineering and Nanomedicine, National Health Research Institutes, 35, Keyan Road, Zhunan Town, Miaoli County, 35053, Taiwan. ldliao@nhri.edu.tw.ORCID http://orcid.org/0000-0002-2601-3673

Funding

National Health Research Institutes NHRI-EX108-10829EINational Health Research Institutes NHRI-EX111-11111EINational Health Research Institutes NHRI-EX111-11129EINational Science and Technology Council 10-2221-E-400-003-MY3National Science and Technology Council 110-2314-B-007-005National Science and Technology Council 111-2221-E-005-018National Science and Technology Council 111-2221-E-035-015National Science and Technology Council 111-2314-B-075-006National Science and Technology Council 111-3114-8-400-001National Science and Technology Council 112-2221-E-005-042
6 · The paper itself

Abstract

Proper organ functioning relies on adequate blood circulation; thus, monitoring blood flow is crucial for early disease diagnosis. Laser speckle contrast imaging (LSCI) is a noninvasive technique that is widely used for measuring superficial blood flow. In this study, we developed a portable LSCI system using an 805-nm near-infrared laser and a monochrome CMOS camera with a 10 × macro zoom lens. The system achieved a high-resolution imaging (1280 × 1024 pixels) with a working distance of 10 to 35 cm. The relative flow velocities were visualized via a spatial speckle contrast analysis algorithm with a 5 × 5 sliding window. In vitro experiments demonstrated the system's ability to image flow velocities in a fluid model, and a linear relationship was observed between the actual flow rate and the relative flow rate obtained by the system. The correlation coefficient (R

Indexed as

Laser Speckle Contrast ImagingAlgorithmsAnimalsBlood Flow VelocityHumansLaser-Doppler FlowmetryLasersMaleRatsRats, Sprague-DawleyRegional Blood FlowBlood circulationBlood flow imagingBlood flow measurementLaser Doppler flowmetryLaser speckle contrast imagingSpeckle contrast analysis

Identifiers

PMID39446280

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.