Evidence map›Paper›PMID 39446247›Full record

ArticleArchives of osteoporosis2024

Bilateral lumbar pedicle fracture in a patient receiving long-term bisphosphonate therapy: a case report with pathological evaluation.

Ryo Fujita, Kota Suda, Zen-Ichi Tanei, Satoko Matsumoto Harmon, Miki Komatsu, Keiichi Nakai, Kento Inomata, Shin Matsushima, Tsutomu Endo, Katsuhisa Yamada and 2 more

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In one paragraph

Article in Archives of osteoporosis, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Ryo FujitaHokkaido Spinal Cord Injury Center, Higashi-4, Minami-1, 3-1, Bibai, Hokkaido, Japan. chm-l-mln-ryo1111@hotmail.co.jp.
Kota SudaHokkaido Spinal Cord Injury Center, Higashi-4, Minami-1, 3-1, Bibai, Hokkaido, Japan.
Zen-Ichi TaneiDepartment of Cancer Pathology, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, Japan.
Satoko Matsumoto HarmonHokkaido Spinal Cord Injury Center, Higashi-4, Minami-1, 3-1, Bibai, Hokkaido, Japan.
Miki KomatsuHokkaido Spinal Cord Injury Center, Higashi-4, Minami-1, 3-1, Bibai, Hokkaido, Japan.
Keiichi NakaiHokkaido Spinal Cord Injury Center, Higashi-4, Minami-1, 3-1, Bibai, Hokkaido, Japan.
Kento InomataHokkaido Spinal Cord Injury Center, Higashi-4, Minami-1, 3-1, Bibai, Hokkaido, Japan.
Shin MatsushimaHokkaido Spinal Cord Injury Center, Higashi-4, Minami-1, 3-1, Bibai, Hokkaido, Japan.
Tsutomu EndoDepartment of Orthopedic Surgery, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, Japan.
Katsuhisa YamadaDepartment of Orthopedic Surgery, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, Japan.
Masahiko TakahataDepartment of Orthopedic Surgery, Dokkyo Medical University, Tochigi, Japan.
Norimasa IwasakiDepartment of Orthopedic Surgery, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBilateral pedicle fractures of the lumbar spine are uncommon and are typically associated with strenuous activities, traumatic events, or previous spinal surgery. This study reported a case of bilateral pedicle fracture in a patient with a long history of osteoporosis treatment with bisphosphonate and included a histological evaluation of the bone. CASE PRESENTATION: An 82-year-old woman with no history of trauma presented to our hospital with back pain that had worsened over the previous month. Computed tomography and magnetic resonance imaging revealed bilateral pedicle fractures of the third lumbar vertebra. She had osteoporosis and had been taking bisphosphonates for 9 years. The patient underwent posterior lumbar fusion, and her symptoms improved. Bone biopsy results from the spinous process revealed few osteoblasts and an absence of osteoclasts, indicating low bone turnover.

conclusionsLong-term use of bisphosphonates may contribute to the development of atypical bilateral pedicle fractures in patients with osteoporosis.

Indexed as

Bone Density Conservation AgentsDiphosphonatesLumbar VertebraeOsteoporosisSpinal FracturesAged, 80 and overFemaleHumansMagnetic Resonance ImagingSpinal FusionTomography, X-Ray ComputedBone Density Conservation AgentsDiphosphonatesAtypical fractureBilateral pedicle fractureBisphosphonateLow bone turnoverOsteoporosis

Identifiers

PMID39446247

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.