Evidence map›Paper›PMID 39446195›Full record

ArticleInternational journal of hematology2025

Misleading antigenic von Willebrand factor levels in acquired von Willebrand syndrome secondary to monoclonal gammopathy of undetermined significance.

Shuichi Okamoto, Atsuo Suzuki, Shogo Tamura, Nobuaki Suzuki, Takeshi Kanematsu, Naruko Suzuki, Yoshino Kawaguchi, Akira Katsumi, Fumihiko Hayakawa, Hitoshi Kiyoi and 2 more

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In one paragraph

Article in International journal of hematology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Shuichi OkamotoDepartment of Laboratory Medicine, Nagoya University Hospital, Nagoya, Japan. okamoto.shuichi.c0@f.mail.nagoya-u.ac.jp.ORCID http://orcid.org/0000-0002-2751-4904
Atsuo SuzukiDepartment of Medical Technique, Nagoya University Hospital, Nagoya, Japan.
Shogo TamuraGraduate School of Health Sciences, Hokkaido University, Sapporo, Japan.
Nobuaki SuzukiDepartment of Transfusion Medicine, Nagoya University Hospital, Nagoya, Japan.
Takeshi KanematsuDepartment of Laboratory Medicine, Nagoya University Hospital, Nagoya, Japan.
Naruko SuzukiDepartment of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Yoshino KawaguchiDepartment of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Akira KatsumiDepartment of Hematology, National Center for Geriatrics and Gerontology, Obu, Japan.
Fumihiko HayakawaDivision of Cellular and Genetic Sciences, Department of Integrated Health Sciences, Nagoya University Graduate School of Medicine, 1-1-20 Daiko-Minami, Higashi-ku, Nagoya, Aichi, 466-8560, Japan.
Hitoshi KiyoiDepartment of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Tetsuhito KojimaDivision of Cellular and Genetic Sciences, Department of Integrated Health Sciences, Nagoya University Graduate School of Medicine, 1-1-20 Daiko-Minami, Higashi-ku, Nagoya, Aichi, 466-8560, Japan.
Tadashi MatsushitaDepartment of Laboratory Medicine, Nagoya University Hospital, Nagoya, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the diagnosis and treatment of acquired von Willebrand syndrome (AVWS), von Willebrand factor (VWF) antigen levels (VWF:Ag) are helpful for quantifying blood VWF-protein levels. Most clinical laboratories measure VWF:Ag by latex immunoassay (LIA), but underlying diseases of AVWS may influence LIA results. A 60 year-old AVWS patient with immunoglobulin G (IgG) kappa-type monoclonal gammopathy of undetermined significance (MGUS) showed reduced VWF activity but normal levels of VWF:Ag. His VWF multimers were broadly decreased, which represented a large discrepancy with VWF:Ag. To investigate the mechanism of this discrepancy, we measured the patient's plasma VWF:Ag by in-house enzyme-linked immunosorbent assay (ELISA) and LIA. We also purified the IgG fraction from the patient's serum and measured VWF:Ag in VWF-deficient plasma supplemented with this fraction. VWF:Ag measured by in-house ELISA (VWF:Ag

Indexed as

Monoclonal Gammopathy of Undetermined Significancevon Willebrand Diseasesvon Willebrand FactorEnzyme-Linked Immunosorbent AssayHumansImmunoglobulin GMaleMiddle AgedImmunoglobulin Gvon Willebrand FactorAcquired von Willebrand syndromeLatex immunoassayMonoclonal gammopathy of undetermined significance

Identifiers

PMID39446195

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.