Evidence map›Paper›PMID 39446161›Full record

ArticleMikrochimica acta2024

An innovative strategy for Gefitinib quantification in pharmaceutical and plasma samples using a graphene quantum dots-combined gold nanoparticles composite electrochemical sensor.

Jieping Cao, Yingmei Shi, Juntong Chen, Zhibin Yan, Minmin Zhang, Mingliang Jin, Lingling Shui, Zhenping Liu, Huiling Feng

Abstract read
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In one paragraph

Article in Mikrochimica acta, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jieping CaoGuangdong Provincial Key Laboratory of Nanophotonic Functional Materials and Devices, School of Information and Optoelectronic Science and Engineering, South China Normal University, Guangzhou, 510006, PR China.
Yingmei ShiGuangdong Provincial Key Laboratory of Nanophotonic Functional Materials and Devices, School of Information and Optoelectronic Science and Engineering, South China Normal University, Guangzhou, 510006, PR China.
Juntong ChenGuangdong Provincial Key Laboratory of Nanophotonic Functional Materials and Devices, School of Information and Optoelectronic Science and Engineering, South China Normal University, Guangzhou, 510006, PR China.
Zhibin YanJoint Laboratory of Optofluidic Technology and System,National Center for International Research on Green Optoelectronics, South China Normal University, Guangzhou, 510006, PR China.
Minmin ZhangGuangdong Provincial Key Laboratory of Nanophotonic Functional Materials and Devices, School of Information and Optoelectronic Science and Engineering, South China Normal University, Guangzhou, 510006, PR China.
Mingliang JinJoint Laboratory of Optofluidic Technology and System,National Center for International Research on Green Optoelectronics, South China Normal University, Guangzhou, 510006, PR China.
Lingling ShuiGuangdong Provincial Key Laboratory of Nanophotonic Functional Materials and Devices, School of Information and Optoelectronic Science and Engineering, South China Normal University, Guangzhou, 510006, PR China. shuill@m.scnu.edu.cn.
Zhenping LiuJoint Laboratory of Optofluidic Technology and System,National Center for International Research on Green Optoelectronics, South China Normal University, Guangzhou, 510006, PR China. liuzhenping@m.scnu.edu.cn.
Huiling FengDepartment of pharmacy, Ganzhou People's Hospital, Ganzhou, 341000, PR China. fenghuilinggzsrmyy@163.com.

Funding

the Guangdong Province Basic and Applied Basic Research Foundation 2023A1515012471the key area special project of ordinary universities in Guangdong province 2024ZDZX2035the National Natural science foundation of China 12372262the National Natural science foundation of China 62004070
6 · The paper itself

Abstract

An innovative methodology is proposed for quantifying Gefitinib (GFT) using an electrochemical sensor constructed from a composite of graphene quantum dots (GQDs) and gold nanoparticles (AuNPs). GQDs were synthesized from graphite, preserving graphene's large surface area and excellent electron transfer capabilities while enhancing dispersibility. The combination of GQDs with AuNPs resulted in an AuNPs@GQDs composite, which was used to construct the sensor. The synthesized nanomaterials were characterized using scanning electron microscopy (SEM) and transmission electron microscopy (TEM), and the electrochemical performance of the sensor was evaluated via cyclic voltammetry (CV) and differential pulse voltammetry (DPV). Under optimized conditions, the sensor displayed a linear calibration curve for GFT detection within the range 0.01 to 10.0 µM, with a limit of detection (LOD) of 0.005 µM (S/N = 3). The sensor demonstrated excellent anti-interference properties and stability in tests using pharmaceutical formulations and plasma samples. Compared to chromatographic methods, the sensor exhibited similar accuracy and recovery. Its easy fabrication and high sensitivity make it a promising tool for pharmaceutical analysis and clinical therapeutic drug monitoring.

Indexed as

Electrochemical TechniquesGefitinibGoldGraphiteLimit of DetectionMetal NanoparticlesQuantum DotsHumansGefitinibGoldGraphiteDifferential pulse voltammetryElectrochemical sensingGefitinibGraphene quantum dotsModified glassy carbon electrodePharmaceutical formulationPlasma sample

Identifiers

PMID39446161

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.