Evidence map›Paper›PMID 39446160›Full record

ArticleActa diabetologica2025

Microvascular changes in eyes with non-proliferative diabetic retinopathy with or without macular microaneurysms: an OCT-angiography study.

Caterina Toma, Elena Cavallari, Paola Varano, Andrea Servillo, Valentina Gatti, Daniela Ferrante, Emanuele Torti, Andrea Muraca, Stefano De Cillà

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Article in Acta diabetologica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
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1 · What the graph read from it

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3 · Its place in the literature

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1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Caterina TomaEye Clinic, University Hospital Maggiore della Carità, Novara, Italy. tomacaterina@gmail.com.ORCID http://orcid.org/0000-0002-1505-6029
Elena CavallariDepartment of Health Sciences, University of Eastern Piedmont "A. Avogadro", Novara, Italy.
Paola VaranoDepartment of Health Sciences, University of Eastern Piedmont "A. Avogadro", Novara, Italy.
Andrea ServilloDepartment of Ophthalmology, IRCCS San Raffaele Hospital, Milan, Italy.
Valentina GattiEye Clinic, University Hospital Maggiore della Carità, Novara, Italy.
Daniela FerranteDepartment of Translational Medicine, University of Eastern Piedmont "A. Avogadro", Novara, Italy.
Emanuele TortiDepartment of Electrical, Computer and Biomedical Engineering, University of Pavia, Pavia, Italy.
Andrea MuracaEye Clinic, University Hospital Maggiore della Carità, Novara, Italy.
Stefano De CillàEye Clinic, University Hospital Maggiore della Carità, Novara, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo evaluate different quantitative non-invasive retinal biomarkers of microvascular impairment and neurodegeneration in patients affected by mild and moderate non proliferative diabetic retinopathy (NPDR) with or without macular microaneurysms (MAs).

methodsA cross-sectional case-control study. Ninety-seven eyes with NPDR, 49 with no central MAs and 48 with central MAs, underwent color fundus photography and optical coherence tomography (OCT)/OCT-angiography (OCT-A). Thickness of central macula, retinal nerve fiber layer (NFL), ganglion cell layer (GCL+) and NFL + GCL + was evaluated on OCT. FAZ metrics (ImageJ), perfusion and vessel density (PD/VD), and fractal dimension (FD) (MATLAB) were evaluated on 3 × 3 OCT-A slabs of both superficial and deep capillary plexuses (SCP/DCP). All evaluations were performed on the full image and after subdivision in 4 quadrants.

resultsIn the MA group, 77 MAs were detected (45.5% in the DCP). The MA group showed: increased FAZ area and perimeter in the SCP (p < 0.01) and DCP (p = 0.02), and reduced circularity index in the SCP (p = 0.03); reduced VD in the SCP (p < 0.01) and reduced PD, VD (p < 0.01) and FD (p = 0.02) in the DCP; decreased VD and FD in the SCP (p = 0.02 and p = 0.05), and in VD and FD in the DCP in the inferior quadrant (p = 0.04 and p = 0.03); a decrease in VD in the SCP in the nasal quadrant (p = 0.05). No differences have been detected in OCT parameters.

conclusionsOur results suggest that the presence of central MAs in patients with NPDR may correlate with more pronounced macular microvascular impairment, particularly during the mild and moderate stages of the disease.

Indexed as

Diabetic RetinopathyMacula LuteaMicroaneurysmMicrovesselsRetinal VesselsAdultAgedCase-Control StudiesCross-Sectional StudiesFemaleFluorescein AngiographyHumansMaleMiddle AgedTomography, Optical CoherenceDiabetic macular ischemiaDiabetic retinopathyMicroaneurysmsNeurodegenerationOptical coherence tomographyOptical coherence tomography angiography

Identifiers

PMID39446160

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