Evidence map›Paper›PMID 39446074›Full record

ArticleAngewandte Chemie (International ed. in English)2025

Unveiling the influence of oxygen on drug release dynamics in semipermeable polymersomes.

Matteo Tollemeto, Pascal L W Welzen, Lasse H E Thamdrup, Yudong Li, Tania Patiño Padial, Anja Boisen, Jan van Hest

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Matteo TollemetoThe Danish National Research Foundation and Villum Foundation's Center IDUN Department of Health Technology, Technical University of Denmark, Kgs. Lyngby, Denmark.ORCID https://orcid.org/0000-0002-6220-2877
Pascal L W WelzenDepartment of Biomedical Engineering, Institute for Complex Molecular Systems, Eindhoven University of Technology, Eindhoven, The Netherland.
Lasse H E ThamdrupThe Danish National Research Foundation and Villum Foundation's Center IDUN Department of Health Technology, Technical University of Denmark, Kgs. Lyngby, Denmark.
Yudong LiDepartment of Biomedical Engineering, Institute for Complex Molecular Systems, Eindhoven University of Technology, Eindhoven, The Netherland.
Tania Patiño PadialDepartment of Biomedical Engineering, Institute for Complex Molecular Systems, Eindhoven University of Technology, Eindhoven, The Netherland.
Anja BoisenThe Danish National Research Foundation and Villum Foundation's Center IDUN Department of Health Technology, Technical University of Denmark, Kgs. Lyngby, Denmark.
Jan van HestDepartment of Biomedical Engineering, Institute for Complex Molecular Systems, Eindhoven University of Technology, Eindhoven, The Netherland.

Funding

Danmarks Grundforskningsfond DNRF122HORIZON EUROPE European Research Council 101054945Novo Nordisk Fonden NNF17OC0026910Villum Fonden 9301
6 · The paper itself

Abstract

Semipermeable polymersomes, a class of polymeric vesicles that allow molecular passage across their membranes, offer significant potential for controlled drug delivery. These vesicles can be designed for inherent or selective permeability through the choice of suitable copolymers or the incorporation of protein nanopores, respectively. In this study, we explore a novel approach using oxygen-producing enzymatic reactions within biodegradable poly(ethylene glycol)-poly(caprolactone-gradient-trimethylene carbonate) (PEG-p(CL-g-TMC)) polymersomes to modulate drug release. These polymersomes were found to enhance the release of hydrophobic drugs while retaining hydrophilic drugs. The enzymatic generation of oxygen within the polymersomes increased membrane hydrophobicity, influencing drug release kinetics. The findings highlight the importance of understanding drug release kinetics in designing effective drug delivery systems, as the release rate and mechanism critically impact therapeutic efficacy and patient outcomes.

Indexed as

Drug CarriersOxygenPolyethylene GlycolsPolymersDrug LiberationHydrophobic and Hydrophilic InteractionsKineticsPermeabilityPolyestersDrug CarriersOxygenPolyestersPolyethylene GlycolsPolymersControlled drug deliveryDrug release kineticsPolymersomesTriggered permeability

Identifiers

PMID39446074
PMCPMC11796314

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.