Evidence map›Paper›PMID 39445806›Full record

ArticlemSphere2024

Mouse innate resistance to

R S Coombs, A E Overacre-Delgoffe, A Bhattacharjee, T W Hand, J P Boyle

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mSphere, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

R S CoombsDepartment of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.ORCID 0000-0001-5064-6270
A E Overacre-DelgoffeDepartment of Immunology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
A BhattacharjeeDepartment of Immunology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
T W HandDepartment of Immunology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
J P BoyleDepartment of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.ORCID 0000-0003-0000-9243

Funding

VECTOR CORE FACILITYP30CA047904 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CHRISTOPHER J. BAKKENIST · 1988 to 2026
$158.0M
Training in Cellular & Molecular Mechanisms of Tumor RejectionT32CA082084 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Robert J Binder, Dario AA Vignali · 1999 to 2026
$9.2M
Comparative and functional genomics of Toxoplasma and Hammondia hammondiR01AI116855 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BOYLE, JON P · 2015 to 2024
$3.2M
Finishing multiple genomes in EupathDB using Oxford Nanopore Single Molecule sequencingR21AI154386 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BOYLE, JON P · 2020 to 2021
$457k
Defining the role of the mucosal immune response and microbiota in enteropathy-driven oral vaccine failureR21AI142051 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HAND, TIMOTHY WESLEY · 2019 to 2020
$412k
Defining an immunological mechanism for a microbiota-based therapy for colorectal cancerR21CA249074 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HAND, TIMOTHY WESLEY · 2020 to 2021
$364k
Damon Runyon Cancer Research Foundation (DRCRF) DRCRFHHS | National Institutes of Health (NIH) T325T32CA082084HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) R01AI116855HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) R21AI142051NCI NIH HHS P30 CA047904NCI NIH HHS R21 CA249074NCI NIH HHS T32 CA082084NIAID NIH HHS R01 AI116855NIAID NIH HHS R21 AI142051NIAID NIH HHS R21 AI154386
6 · The paper itself

Abstract

IMPORTANCE: Pathogen differences in host range are poorly understood at the molecular level even though even closely related pathogen species can have dramatically distinct host ranges. Here, we study two related parasite species that have a dramatic difference in their ability to infect mice. Here, we show that soluble proteins from these species determine one driver of this difference: induction of interferon gamma by cells of the innate immune system.

Indexed as

CoccidiosisImmunity, InnateInterferon-gammaKiller Cells, NaturalMice, Inbred C57BLNeosporaAnimalsFemaleLigandsMiceMice, KnockoutToxoplasmaInterferon-gammaLigandsinnate immune responseinterferon γnatural killer cellsNeospora caninumToxoplasma gondii

Identifiers

PMID39445806
PMCPMC11580461

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.