Evidence map›Paper›PMID 39445624›Full record

ArticleKnee surgery, sports traumatology, arthroscopy : official journal of the ESSKA2025

Evaluation of a novel robotic testing method for stability and kinematics of total knee arthroplasty.

Sander R Holthof, Mick Rock, Richard van Arkel, Angela Brivio, David Barrett, Andrew A Amis

Abstract readEvaluation Study
In one paragraph

Article in Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Total knee replacement designs have differing stability under novel robotic testing method in vitro.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2025
    Article
  3. Evaluation of a novel robotic testing method for stability and kinematics of total knee arthroplasty.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sander R HolthofBiomechanics Group, Mechanical Engineering Department, Imperial College London, London, UK.
Mick RockDe Puy Synthes Ltd, Beeston, Leeds, UK.
Richard van ArkelBiomechanics Group, Mechanical Engineering Department, Imperial College London, London, UK.
Angela BrivioKing Edward VII Hospital, London, UK.
David BarrettKing Edward VII Hospital, London, UK.
Andrew A AmisBiomechanics Group, Mechanical Engineering Department, Imperial College London, London, UK.ORCID http://orcid.org/0000-0002-4489-1381

Funding

De Puy Synthes Ltd
6 · The paper itself

Abstract

purposeThis work developed a novel preclinical test of total knee replacements (TKRs) in order to explain TKR instability linked to patient dissatisfaction. It was hypothesized that stability tests on the isolated moving prostheses would provide novel comparative data on the stability and kinematics among TKR designs.

methodsThree TKR designs, DePuy Synthes Attune MS, Stryker Triathlon and Zimmer Biomet Persona MC, were assessed using a robotic arm while flexing-extending 0-140°. Tests imposed 710 N body weight combined with three tibial loads: no anterior-posterior (AP) force, 90 N anterior or 90 N posterior force. Other load effects were minimized and the kinematics was recorded. Each implant was tested six times to investigate the repeatability of the method. Data were analysed using statistical parametric mapping with one-way analysis of variance (ANOVA). If significance was found (p < 0.05), post hoc t tests with Bonferroni correction were used to contrast groups.

resultsSignificant differences were found throughout flexion-extension. Femoral rollback, AP stability, coupled internal-external rotation and AP position (roll-back) were all influenced by implant design. AP stability of the TKRs reduced with flexion reaching Attune 15 mm, Persona 13 mm and Triathlon 21 mm at 140° flexion. Tractive rolling significantly affected kinematics in the less congruent Triathlon design, with 6 mm different paths between flexion and extension motion (p < 0.05 across 5-100°). Paradoxical anterior femoral sliding in early flexion (0-40°) occurred in Persona and Triathlon designs.

conclusionsThe novel testing technique provides, for the first time, comparative data on the inherent stability and kinematics of the TKR implants themselves across the arc of flexion-extension, independent of variables including soft tissue behaviour and surgical technique. The data show how much each prosthesis can contribute to the stability and motion of the implanted knee. Similar data from a wider range of designs will enable more informed decisions regarding implant design choice, aiming to reduce the prevalence of TKR instability in patients. LEVEL OF EVIDENCE: Controlled laboratory study.

Indexed as

Knee ProsthesisMaterials TestingRoboticsBiomechanical PhenomenaHumansJoint InstabilityKnee JointPatient SatisfactionProsthesis Designinstabilitykinematicsprosthesisreplacementrobotic testingtotal knee arthroplasty

Identifiers

PMID39445624
PMCPMC11948167

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.