Evidence map›Paper›PMID 39445493›Full record

ArticlePublic health nutrition2024

Improvement of serum folate status in the US women of reproductive age with fortified iodised salt with folic acid (FISFA study).

Anastasia Arynchyna-Smith, Alexander N Arynchyn, Vijaya Kancherla, Kenneth Anselmi, Inmaculada Aban, Ron C Hoogeveen, Lyn M Steffen, David J Becker, Andrzej Kulczycki, Waldemar A Carlo and 1 more

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In one paragraph

Article in Public health nutrition, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. International journal of molecular medicine · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Anastasia Arynchyna-SmithDivision of Pediatric Neurosurgery, Department of Neurosurgery, University of Alabama at Birmingham, 1600 7th Ave South, JFL 400, Birmingham, AL35233, USA.ORCID 0000-0002-2863-5388
Alexander N ArynchynDivision of Preventive Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Vijaya KancherlaDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
Kenneth AnselmiDepartment of Marketing and Supply Chain Management, College of Business, East Carolina University, Greenville, NC, USA.
Inmaculada AbanDepartment of Biostatistics, School of Public Health, University of Alabama at Birmingham, Birmingham, AL, USA.
Ron C HoogeveenDepartment of Medicine, Baylor College of Medicine, Houston, TX, USA.
Lyn M SteffenDivision of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN, USA.
David J BeckerDepartment of Health Policy and Organization, School of Public Health, University of Alabama at Birmingham, Birmingham, AL, USA.
Andrzej KulczyckiDepartment of Health Policy and Organization, School of Public Health, University of Alabama at Birmingham, Birmingham, AL, USA.
Waldemar A CarloDivision of Neonatology, Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL, USA.
Jeffrey P BlountDivision of Pediatric Neurosurgery, Department of Neurosurgery, University of Alabama at Birmingham, 1600 7th Ave South, JFL 400, Birmingham, AL35233, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveMandatory folic acid fortification of enriched grains has reduced neural tube defect prevalence in several countries. We examined salt as an additional vehicle for folic acid fortification. The primary objective was to examine the change in serum folate concentration after 1 month of consumption of fortified iodised salt with folic acid (FISFA) among women of reproductive age. The secondary objectives were to examine (1) the feasibility of implementing FISFA intervention and (2) the acceptability of FISFA.

designWe conducted a pre–post intervention study (January–April 2023). Participants received a FISFA saltshaker with the study salt (1 g of sodium chloride salt fortified with 100 mcg of folic acid) to use instead of regular table salt for 1 month. Serum folate was measured using the Elecsys Folate-III immunoassay method at baseline and 1-month endpoint. Change in serum folate was assessed using a two-tailed Wilcoxon signed rank test for paired samples.

settingMetropolitan city, Southern USA.

participantsNon-pregnant, 18–40-year-old women who lived alone/with a partner.

resultsThirty-two eligible women consented to participate, including eleven non-Hispanic-White, eleven non-Hispanic-Black and ten Hispanic. Post-intervention, there was a significant increase in median serum folate concentration of 1·40 nmol/l (IQR 0·74–2·05;

conclusionsFISFA is an effective approach to increasing serum folate concentrations among women of reproductive age. Findings should be replicated in a larger study.

Indexed as

Folic AcidFood, FortifiedIodineSodium Chloride, DietaryAdolescentAdultFemaleHumansNeural Tube DefectsNutritional StatusUnited StatesYoung AdultFolic AcidIodineiodized saltSodium Chloride, DietaryFolic acidFood fortificationInterventionIodised saltNeural tube defectsPreventionSerum folate concentrationSpina bifida

Identifiers

PMID39445493
PMCPMC11604329

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.