Evidence map›Paper›PMID 39445111›Full record

ArticleHorticulture research2024

Engineered dsRNA-protein nanoparticles for effective systemic gene silencing in plants.

Huayu Sun, Ankarao Kalluri, Dan Tang, Jingwen Ding, Longmei Zhai, Xianbin Gu, Yanjun Li, Huseyin Yer, Xiaohan Yang, Gerald A Tuskan and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Horticulture research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Development and Future Prospects of Bamboo Gene Science.International journal of molecular sciences · 2025
    Review
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Huayu SunDepartment of Plant Science and Landscape Architecture, University of Connecticut, Storrs, CT 06269, USA.ORCID https://orcid.org/0000-0002-6532-7018
Ankarao KalluriDepartment of Material Science, University of Connecticut, Storrs, CT 06269, USA.
Dan TangDepartment of Plant Science and Landscape Architecture, University of Connecticut, Storrs, CT 06269, USA.
Jingwen DingDepartment of Chemistry, University of Connecticut, Storrs, CT 06269, USA.
Longmei ZhaiDepartment of Plant Science and Landscape Architecture, University of Connecticut, Storrs, CT 06269, USA.
Xianbin GuDepartment of Plant Science and Landscape Architecture, University of Connecticut, Storrs, CT 06269, USA.
Yanjun LiDepartment of Plant Science and Landscape Architecture, University of Connecticut, Storrs, CT 06269, USA.
Huseyin YerDepartment of Plant Science and Landscape Architecture, University of Connecticut, Storrs, CT 06269, USA.
Xiaohan YangBiosciences Division, Center for Bioenergy Innovation, Oak Ridge National Laboratory, Oak Ridge, TN 37831, USA.
Gerald A TuskanBiosciences Division, Center for Bioenergy Innovation, Oak Ridge National Laboratory, Oak Ridge, TN 37831, USA.
Zhanao DengCitrus Research and Education Center, University of Florida, IFAS, Lake Alfred, FL 33850, USA.
Frederick G GmitterUSDA-ARS, U.S. National Arboretum, Floral and Nursery Plants Research Unit, Beltsville Agricultural Research Center (BARC)-West, Beltsville, MD 20705, USA.
Hui DuanDepartment of Molecular and Cellular Biology, University of Connecticut, Storrs, CT 06269, USA.ORCID https://orcid.org/0000-0002-0142-3262
Challa KumarDepartment of Material Science, University of Connecticut, Storrs, CT 06269, USA.
Yi LiDepartment of Plant Science and Landscape Architecture, University of Connecticut, Storrs, CT 06269, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Long-distance transport or systemic silencing effects of exogenous biologically active RNA molecules in higher plants have not been reported. Here, we report that cationized bovine serum albumin (cBSA) avidly binds double-stranded beta-glucuronidase RNA (dsGUS RNA) to form nucleic acid-protein nanocomplexes. In our experiments with tobacco and poplar plants, we have successfully demonstrated systemic gene silencing effects of cBSA/dsGUS RNA nanocomplexes when we locally applied the nanocomplexes from the basal ends of leaf petioles or shoots. We have further demonstrated that the cBSA/dsGUS RNA nanocomplexes are highly effective in silencing both the conditionally inducible

Identifiers

PMID39445111
PMCPMC11497610

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.