Evidence map›Paper›PMID 39445068›Full record

ArticleThe journal of venomous animals and toxins including tropical diseases2024

Immunomodulatory effect of

Cindy Gabriela Rivera Tobar, Yisel Del Mar Morales Urmendiz, Marcela Alejandra Vallejo, Diego Felipe Manquillo, Victoria Eugenia Niño Castaño, Ana Isabel Ospina Caicedo, Leydy Lorena Mendoza Tobar, Jimmy Alexander Guerrero Vargas, Rosa Amalia Dueñas Cuellar

Abstract read
In one paragraph

Article in The journal of venomous animals and toxins including tropical diseases, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Influence of envenomation timing on peripheral immune and oxidative responses in experimental scorpion envenomation.The journal of venomous animals and toxins including tropical diseases · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Cindy Gabriela Rivera TobarGrupo de Investigación en Inmunología y Enfermedades Infecciosas, Programa de Medicina, Departamento de Patología, Facultad de Ciencias de la Salud, Universidad del Cauca, Popayán, Colombia.ORCID 0009-0002-6743-667X
Yisel Del Mar Morales UrmendizGrupo de Investigación en Inmunología y Enfermedades Infecciosas, Programa de Medicina, Departamento de Patología, Facultad de Ciencias de la Salud, Universidad del Cauca, Popayán, Colombia.ORCID 0000-0002-8609-7020
Marcela Alejandra VallejoGrupo de Investigación en Inmunología y Enfermedades Infecciosas, Programa de Medicina, Departamento de Patología, Facultad de Ciencias de la Salud, Universidad del Cauca, Popayán, Colombia.ORCID 0009-0004-5516-1896
Diego Felipe ManquilloGrupo de Investigación en Inmunología y Enfermedades Infecciosas, Programa de Medicina, Departamento de Patología, Facultad de Ciencias de la Salud, Universidad del Cauca, Popayán, Colombia.ORCID 0009-0008-5047-9466
Victoria Eugenia Niño CastañoGrupo de Investigación en Inmunología y Enfermedades Infecciosas, Programa de Medicina, Departamento de Patología, Facultad de Ciencias de la Salud, Universidad del Cauca, Popayán, Colombia.ORCID 0000-0002-7726-3613
Ana Isabel Ospina CaicedoGrupo de Investigación en Salud, Programa de Medicina, Departamento de Medicina Interna, Facultad de Ciencias de la Salud, Universidad del Cauca, Popayán, Colombia.ORCID 0000-0002-1418-7481
Leydy Lorena Mendoza TobarGrupo de Investigaciones Herpetológicas y Toxinológicas (GIHT), Departamento de Biología, Facultad de Ciencias Naturales, Exactas y de la Educación, Universidad del Cauca, Popayán, Colombia.ORCID 0000-0003-0356-0903
Jimmy Alexander Guerrero VargasGrupo de Investigaciones Herpetológicas y Toxinológicas (GIHT), Departamento de Biología, Facultad de Ciencias Naturales, Exactas y de la Educación, Universidad del Cauca, Popayán, Colombia.ORCID 0000-0002-0193-5508
Rosa Amalia Dueñas CuellarGrupo de Investigación en Inmunología y Enfermedades Infecciosas, Programa de Medicina, Departamento de Patología, Facultad de Ciencias de la Salud, Universidad del Cauca, Popayán, Colombia.ORCID 0000-0002-2157-1131

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Pathophysiological mechanisms of rheumatoid arthritis arise because of a proinflammatory environment, generated by the interaction of autoreactive lymphocytes and proinflammatory mediators. Current strategies to mitigate the progression of the disease produce adverse effects, so there is a need for new therapeutic strategies and molecular targets to treat this disease. In this context, evidence suggests that scorpion venoms could modulate the immune response and some important cellular mechanisms of pharmacological interest. To evaluate the immunomodulatory effect of the venom of Methods: A case-control study was conducted with a sample of 10 women with a confirmed diagnosis of RA and controls matched by sex and age. The cytotoxicity of the venom was evaluated to find sublethal concentrations of the venom, and subsequently, their immunomodulatory capacity in terms of percentage of proliferation, cell activation, and cytokines production. Results: the venom of Conclusion: the venom of

Indexed as

ActivationFlow cytometryImmunomodulatory activityProliferationRheumatoid arthritisTityus aff. metuendusTityus sp.T lymphocytesVenom

Identifiers

PMID39445068
PMCPMC11498904

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.