Evidence map›Paper›PMID 39444898›Full record

ArticleJournal of thoracic disease2024

Spleen aminopeptides (FUKETUO) elevate the therapeutic effect of house dust mite desensitization on allergic asthma by inducing interleukin-10 positive regulatory T cells (IL-10

Yuan Ji, Long Fan, Gaohui Wu, Niu Ding, Cong Liu, Lei Wu, Lanxiang Wang, Donghui Huang, Damo Xu, Xiaojun Xiao and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of thoracic disease, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yuan Ji *Institute of Allergy & Immunology, Shenzhen Key Laboratory of Allergy and Immunology, State Key Laboratory of Respiratory Disease Shenzhen University Division, Shenzhen University School of Medicine, Shenzhen, China.
Long Fan *State Key Laboratory of Dampness Syndrome of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Provincial Hospital of Chinese Medicine, Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China.
Gaohui Wu *Department of Respiratory and Allergy, Third Affiliated Hospital of Shenzhen University, Shenzhen, China.
Niu DingDepartment of Respiratory Medicine, Hunan Children's Hospital, Changsha, China.
Cong LiuInstitute of Biotechnology, Zhejiang Feng'an Bio-Pharmaceutical Co., Ltd., Taizhou, China.
Lei WuState Key Laboratory of Dampness Syndrome of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Provincial Hospital of Chinese Medicine, Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China.
Lanxiang WangDepartment of Respiratory and Allergy, Third Affiliated Hospital of Shenzhen University, Shenzhen, China.
Donghui HuangZhuhai Hospital of Integrated Traditional Chinese and Western Medicine, Zhuhai, China.
Damo XuInstitute of Allergy & Immunology, Shenzhen Key Laboratory of Allergy and Immunology, State Key Laboratory of Respiratory Disease Shenzhen University Division, Shenzhen University School of Medicine, Shenzhen, China.
Xiaojun XiaoInstitute of Allergy & Immunology, Shenzhen Key Laboratory of Allergy and Immunology, State Key Laboratory of Respiratory Disease Shenzhen University Division, Shenzhen University School of Medicine, Shenzhen, China.
Lin LinState Key Laboratory of Dampness Syndrome of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Provincial Hospital of Chinese Medicine, Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China.
Xiaoyu LiuInstitute of Allergy & Immunology, Shenzhen Key Laboratory of Allergy and Immunology, State Key Laboratory of Respiratory Disease Shenzhen University Division, Shenzhen University School of Medicine, Shenzhen, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: As a novel immunomodulator, spleen aminopeptides (FUKETUO) can correct the imbalance of immune cells and elevate their functions. Spleen aminopeptides have been used in the treatment of respiratory diseases. However, the regulatory mechanism of it on allergic asthma and desensitization has not been reported, further study is critically needed. This study aimed to investigate the effect and mechanism of spleen aminopeptides on allergic asthma and desensitization. We established an allergic asthma model by house dust mite (HDM) with/without desensitization treatment. Methods: The allergic asthma mouse model was established with HDM and treated with desensitization and increasing dose of spleen aminopeptides according to different immune phases. Pathological markers such as airway hyper-responsiveness, and cell composition were monitored to determine the effectiveness of treatment. Results: Spleen aminopeptides can promote the proportion of interleukin-10 positive (IL10 Conclusions: Our results suggested that spleen aminopeptides (FUKETUO) could elevate the expression of (CD4

Indexed as

allergic asthmaallergic enteritiseosinophilinterleukin-10 (IL-10)Spleen aminopeptides

Identifiers

PMID39444898
PMCPMC11494541

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.