Evidence map›Paper›PMID 39444533›Full record

ArticleACS catalysis2024

The Role of General Acid Catalysis in the Mechanism of an Alkyl Transferase Ribozyme.

Timothy J Wilson, Erika McCarthy, Şölen Ekesan, Timothy J Giese, Nan-Sheng Li, Lin Huang, Joseph A Piccirilli, Darrin M York, David M J Lilley

Abstract read
In one paragraph

Article in ACS catalysis, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Alkyltransferase Ribozyme for Site-Specific NAngewandte Chemie (International ed. in English) · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. DeePMD-GNN: A DeePMD-kit Plugin for External Graph Neural Network Potentials.Journal of chemical information and modeling · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Timothy J WilsonNucleic Acid Structure Research Group, Division of Molecular, Cellular and Developmental Biology, MSI/WTB Complex, The University of Dundee, Dow Street, Dundee DD1 5EH, U.K.
Erika McCarthyLaboratory for Biomolecular Simulation Research, Institute for Quantitative Biomedicine and Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, New Jersey 08854, United States.ORCID https://orcid.org/0000-0001-8089-0207
Şölen EkesanLaboratory for Biomolecular Simulation Research, Institute for Quantitative Biomedicine and Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, New Jersey 08854, United States.ORCID https://orcid.org/0000-0002-5598-5754
Timothy J GieseLaboratory for Biomolecular Simulation Research, Institute for Quantitative Biomedicine and Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, New Jersey 08854, United States.
Nan-Sheng LiDepartment of Chemistry, The University of Chicago, Chicago, Illinois 60637, United States.
Lin HuangGuangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Guangdong-Hong Kong Joint Laboratory for RNA Medicine, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, P.R. China.ORCID https://orcid.org/0000-0002-2121-365X
Joseph A PiccirilliDepartment of Chemistry, The University of Chicago, Chicago, Illinois 60637, United States.ORCID https://orcid.org/0000-0002-0541-6270
Darrin M YorkLaboratory for Biomolecular Simulation Research, Institute for Quantitative Biomedicine and Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, New Jersey 08854, United States.ORCID https://orcid.org/0000-0002-9193-7055
David M J LilleyNucleic Acid Structure Research Group, Division of Molecular, Cellular and Developmental Biology, MSI/WTB Complex, The University of Dundee, Dow Street, Dundee DD1 5EH, U.K.ORCID https://orcid.org/0000-0001-6882-2818

Funding

Multi-Scale Quantum Models for Ribozyme CatalysisR01GM062248 · NIGMS · UNIVERSITY OF MINNESOTA TWIN CITIES · PI Darrin M York · 2001 to 2026
$7.1M
Structure and Function of Non-Coding RNAR35GM149336 · NIGMS · UNIVERSITY OF CHICAGO · PI Joseph Anthony Piccirilli · 2023 to 2026
$2.8M
NIGMS NIH HHS R01 GM062248NIGMS NIH HHS R35 GM149336
6 · The paper itself

Abstract

MTR1 is an in vitro-selected alkyl transferase ribozyme that transfers an alkyl group from

Identifiers

PMID39444533
PMCPMC11494507

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.