Evidence map›Paper›PMID 39444366›Full record

ArticleImmunology2025

Sphingosine-1-Phosphate Signalling Inhibition Suppresses Th1-Like Treg Generation by Reversing Mitochondrial Uncoupling.

Rachel Coulombeau, Claudia Selck, Nicolas Giang, Abdulrahman Al-Mohammad, Natalie Ng, Allison K Maher, Rafael Argüello, Antonio Scalfari, James Varley, Richard Nicholas and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. T-betThe FEBS journal · 2026
    Article
  3. Article
  4. Sphingolipid Metabolism in the Pathogenesis of Hashimoto's Thyroiditis.International journal of molecular sciences · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Rachel CoulombeauDepartment of Infectious Disease, Faculty of Medicine, Imperial College London, London, UK.
Claudia SelckDepartment of Infectious Disease, Faculty of Medicine, Imperial College London, London, UK.
Nicolas GiangDepartment of Infectious Disease, Faculty of Medicine, Imperial College London, London, UK.
Abdulrahman Al-MohammadSchool of Clinical Medicine, University of Cambridge, Cambridge, UK.
Natalie NgDepartment of Infectious Disease, Faculty of Medicine, Imperial College London, London, UK.ORCID 0009-0001-8120-5491
Allison K MaherDepartment of Infectious Disease, Faculty of Medicine, Imperial College London, London, UK.ORCID 0000-0002-9540-3333
Rafael ArgüelloImmunometabolism and Translation, Aix Marseille Université, CNRS, INSERM, Centre d'Immunologie de Marseille-Luminy, Marseille, France.
Antonio ScalfariCentre of Neuroscience, Department of Medicine, Charing Cross Hospital, London, UK.
James VarleyCentre of Neuroscience, Imperial College Healthcare NHS Trust, London, UK.
Richard NicholasCentre of Neuroscience, Imperial College Healthcare NHS Trust, London, UK.
Margarita Dominguez-VillarDepartment of Infectious Disease, Faculty of Medicine, Imperial College London, London, UK.ORCID 0000-0002-9719-0028

Funding

Biotechnology and Biological Sciences Research Council BB/W001055/1
6 · The paper itself

Abstract

Inflammatory environments induce the generation of dysfunctional IFNγ

Indexed as

Fingolimod HydrochlorideLysophospholipidsMitochondriaMultiple SclerosisSignal TransductionSphingosineTh1 CellsT-Lymphocytes, RegulatoryAdultAnimalsCells, CulturedFemaleHumansMaleMechanistic Target of Rapamycin Complex 1MiceFingolimod HydrochlorideLysophospholipidsMechanistic Target of Rapamycin Complex 1Sphingosinesphingosine 1-phosphateautoimmunityEAE/MSTreg

Identifiers

PMID39444366
PMCPMC11652410

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.