Evidence map›Paper›PMID 39444190›Full record

ArticleAngewandte Chemie (International ed. in English)2025

Light-Activated Gene Expression System Using a Caging-Group-Free Photoactivatable Dye.

Tatsuki Nonomura, Masafumi Minoshima, Kazuya Kikuchi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Tatsuki NonomuraDepartment of Applied Chemistry, Graduate School of Engineering, Osaka University, 2-1, Yamadaoka, Suita, Osaka, 5650871, Japan.
Masafumi MinoshimaDepartment of Applied Chemistry, Graduate School of Engineering, Osaka University, 2-1, Yamadaoka, Suita, Osaka, 5650871, Japan.ORCID 0000-0002-9352-3454
Kazuya KikuchiDepartment of Applied Chemistry, Graduate School of Engineering, Osaka University, 2-1, Yamadaoka, Suita, Osaka, 5650871, Japan.ORCID 0000-0001-7103-1275

Funding

Japan Agency for Medical Research and Development JP24ama121054Japan Society for the Promotion of Science JP22H05425Japan Society for the Promotion of Science JP23H04880, JP23H04881, JP21H04706, JP23KK0106, JP24H00494Precursory Research for Embryonic Science and Technology JPMJPR22EC
6 · The paper itself

Abstract

Optical regulation of transcription using chemical compounds is an effective strategy to manipulate gene expression spatiotemporally. Conventional caging approaches with photoremovable protecting groups may require intense UV-light exposure and release potentially toxic byproducts. To address these problems, here we developed a light-mediated transcriptional regulation system by combining a caging-group-free photoactivatable dye PaX

Indexed as

Coloring AgentsFluorescent DyesLightDNA-Directed RNA PolymerasesHumansTranscriptional ActivationViral Proteinsbacteriophage T7 RNA polymeraseColoring AgentsDNA-Directed RNA PolymerasesFluorescent DyesViral Proteinscell-free transcriptionmultidrug-binding transcriptional regulatoroptical gene expressionphotoactivatable dyetranscriptional regulation

Identifiers

PMID39444190
PMCPMC11753602

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.