Evidence map›Paper›PMID 39444171›Full record

ArticleAnnals of clinical and translational neurology2024

Insular monoaminergic deficits in prodromal α-synucleinopathies.

Andrea Pilotto, Alice Galli, Cinzia Zatti, Fabio Placidi, Francesca Izzi, Enrico Premi, Silvia P Caminiti, Luca Presotto, Andrea Rizzardi, Marcello Catania and 14 more

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In one paragraph

Article in Annals of clinical and translational neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Andrea Pilotto *Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, 25123, Italy.ORCID 0000-0003-2029-6606
Alice Galli *Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, 25123, Italy.ORCID 0009-0009-7804-5106
Cinzia ZattiNeurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, 25123, Italy.ORCID 0009-0001-5648-0408
Fabio PlacidiSleep Medicine Centre, Neurology Unit, University Hospital of Rome Tor Vergata, 00133, Italy.
Francesca IzziSleep Medicine Centre, Neurology Unit, University Hospital of Rome Tor Vergata, 00133, Italy.
Enrico PremiVascular Neurology, ASST Spedali Civili of Brescia, Brescia, 25123, Italy.
Silvia P CaminitiDepartment of Brain and Behavioral Sciences, Univeristy of Pavia, Pavia, 27100, Italy.ORCID 0000-0003-4568-1738
Luca PresottoDepartment of Physics "G. Occhialini", University of Milano-Bicocca, Milan, 20126, Italy.
Andrea RizzardiNeurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, 25123, Italy.ORCID 0009-0008-4568-0018
Marcello CataniaNeurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, 25123, Italy.
Alessandro LupiniNeurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, 25123, Italy.ORCID 0009-0008-0546-6543
Leandro PurinNeurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, 25123, Italy.
Maria P PasoliniSleep Disorder Center, ASST Spedali Civili of Brescia, Brescia, 25123, Italy.
Nicola B MercuriSleep Medicine Centre, Neurology Unit, University Hospital of Rome Tor Vergata, 00133, Italy.ORCID 0000-0001-6700-7491
Agostino ChiaravalottiDepartment of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, 00133, Italy.
Mariana FernandesDepartment of Systems Medicine, University of Rome Tor Vergata, Rome, 00133, Italy.
Carmen CalvelloDepartment of Systems Medicine, University of Rome Tor Vergata, Rome, 00133, Italy.
Silvia LucchiniNuclear Medicine Unit, University of Brescia, Brescia, 25123, Italy.
Francesco BertagnaNuclear Medicine Unit, University of Brescia, Brescia, 25123, Italy.
Barbara PagheraNuclear Medicine Unit, University of Brescia, Brescia, 25123, Italy.
Daniela PeraniVita Salute San-Raffaele University, Milan, 20123, Italy.ORCID 0000-0002-3421-204X
Daniela BergDepartment of Neurology, Christian-Albrechts-University of Kiel, Kiel, 24098, Germany.ORCID 0000-0001-5796-5442
Alessandro PadovaniNeurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, 25123, Italy.ORCID 0000-0002-0119-3639
Claudio LiguoriSleep Medicine Centre, Neurology Unit, University Hospital of Rome Tor Vergata, 00133, Italy.ORCID 0000-0003-2845-1332

Funding

LIMPE-DISMOV Foundation
6 · The paper itself

Abstract

methodsThis study assessed data from two cohorts of patients with alpha-synucleinopathies (University of Brescia and University of Rome Tor-Vergata cohorts). Consecutive participants with video-polysomnography-confirmed iRBD, Parkinson's disease (PD), dementia with Lewy bodies (DLB) and controls underwent neurological, clinical and

resultsThe cohort (n = 184) included 45 patients with iRBD, 47 PD, 42 DLB and 50 age-matched controls. Individuals with iRBD were categorized as RBD-DAT- (n = 32) and RBD-DAT+ (n = 13), according to nigrostriatal assessment used in clinical practice. Compared to controls, RBD-DAT- showed an early involvement of the left insula, which increased in RBD-DAT+, and was present in patients with Parkinson's disease and dementia with Lewy bodies. Longitudinal cox regression analyses revealed a higher risk of phenoconversion in individuals with iRBD and insular monoaminergic deficits [HR = 3.387; CI 95%: 1.18-10.27].

interpretationIn this study, altered insular monoaminergic binding in iRBD was associated with phenoconversion to DLB or PD. These findings may provide a helpful stratification approach for future pharmacological or non-pharmacological interventions.

Indexed as

Lewy Body DiseaseParkinson DiseaseProdromal SymptomsSynucleinopathiesTomography, Emission-Computed, Single-PhotonAgedAged, 80 and overCerebral CortexCohort StudiesFemaleHumansLongitudinal StudiesMaleMiddle AgedREM Sleep Behavior DisorderTropanes2-carbomethoxy-8-(3-fluoropropyl)-3-(4-iodophenyl)tropaneTropanes

Identifiers

PMID39444171
PMCPMC11572750

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.