Evidence map›Paper›PMID 39444045›Full record

ArticleEuropean journal of medical research2024

Surgical treatment of long-term epilepsy-associated tumors guided by stereoelectroencephalography.

Wei Zhang, Qiang Guo, Junxi Chen, Dan Zhu, Qinghua Tan, Liming Zhang, Hainan Li, Baijie Cheng

Abstract read
In one paragraph

Article in European journal of medical research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

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2citing papers in PubMed, 1 pooled it
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1 · What the graph read from it

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3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Wei ZhangDepartment of Neurosurgery, Guangdong Sanjiu Brain Hospital, Guangzhou, China.
Qiang GuoDepartment of Neurosurgery, Guangdong Sanjiu Brain Hospital, Guangzhou, China. guoqiang999brain@163.com.
Junxi ChenDepartment of Neurosurgery, Guangdong Sanjiu Brain Hospital, Guangzhou, China.
Dan ZhuDepartment of Neurosurgery, Guangdong Sanjiu Brain Hospital, Guangzhou, China.
Qinghua TanDepartment of Neurosurgery, Guangdong Sanjiu Brain Hospital, Guangzhou, China.
Liming ZhangDepartment of Neurosurgery, Guangdong Sanjiu Brain Hospital, Guangzhou, China.
Hainan LiDepartment of Pathology, Guangdong Sanjiu Brain Hospital, Guangzhou, China.
Baijie ChengDepartment of Pathology, Guangdong Sanjiu Brain Hospital, Guangzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeAccurate detection and resection of the epileptogenic zone (EZ) in patients with long-term epilepsy-associated tumors (LEATs) are significantly correlated with favorable seizure prognosis. However, the relationship between tumors and the EZ remains unknown. This study aimed to evaluate the spatial relationship between LEATs and the EZ, as well as the electrophysiological features of LEATs.

methodsWe retrospectively studied five patients with LEATs who underwent deep electrode implantation and EZ resection in the hospital. The clinical characteristics, surgical outcomes, localizing features and intracranial SEEG results were reviewed.

resultsOne female and four males (mean age: 25.2 years; median age: 24 years; range: 13-45 years) were included in the study. Five-to-eleven electrodes (mean: 8.4) were implanted per patient. The EZ was located in the tumor and nearby cortex in three cases and in the tumor and distant areas in two cases. Pathological examination revealed ganglioglioma in four cases, two of which were associated with hippocampal sclerosis, and the other case showed a multinodular and vacuolating neuronal tumor with gliosis. All patients were seizure-free for at least 24 months postoperatively.

conclusionsSEEG provides valuable insights into the electrophysiological mechanisms of LEATs. The EZ often contains brain tissue around the tumor. However, only a few cases, particularly those with temporoparietal occipital (TPO) area involvement, a long history of epilepsy and other abnormalities on MRI, such as hippocampal sclerosis and focal cortical dysplasia, may include distant areas.

Indexed as

Brain NeoplasmsElectroencephalographyEpilepsyAdolescentAdultFemaleHumansMaleMiddle AgedRetrospective StudiesTreatment OutcomeYoung AdultEpileptogenic zoneLong-term epilepsy-associated tumorsSeizure-freeStereoelectroencephalographySurgery

Identifiers

PMID39444045
PMCPMC11515466

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