Evidence map›Paper›PMID 39443929›Full record

ArticleBMC public health2024

Global, regional, and national total burden related to hepatitis B in children and adolescents from 1990 to 2021.

Jinbo Li, Ziyi Gao, Hongjing Bai, Weigang Wang, Yandi Li, Jia Lian, Yaling Li, Yongliang Feng, Suping Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC public health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jinbo LiSchool of Public Health, Shanxi Medical University, Taiyuan, China.
Ziyi GaoSchool of Public Health, Shanxi Medical University, Taiyuan, China.
Hongjing BaiSchool of Public Health, Shanxi Medical University, Taiyuan, China.
Weigang WangSchool of Public Health, Shanxi Medical University, Taiyuan, China.
Yandi LiSchool of Public Health, Shanxi Medical University, Taiyuan, China.
Jia LianSchool of Public Health, Shanxi Medical University, Taiyuan, China.
Yaling LiSchool of Public Health, Shanxi Medical University, Taiyuan, China.
Yongliang FengSchool of Public Health, Shanxi Medical University, Taiyuan, China. yongliang.feng@sxmu.edu.cn.
Suping WangSchool of Public Health, Shanxi Medical University, Taiyuan, China. supingwang@sxmu.edu.cn.

Funding

National Natural Science Foundation of China 82073622
6 · The paper itself

Abstract

backgroundHepatitis B remains a significant global health concern with widespread communicability. Nevertheless, data on its burden and trends in children and adolescents were limited. We aim to evaluate the global, regional, and national trends of total burden related to hepatitis B in children and adolescents aged 0-19 years from 1990 to 2021.

methodsThe age-standardized incidence, prevalence, mortality, and disability-adjusted life years (DALYs) were calculated by the Global Burden of Disease (GBD) study from 1990 to 2021. These indicators were stratified by sex, age, socio-demographic index (SDI), and disease stage. We calculated the correlation between them and SDI. The temporal trends were examined using the annual average percentage change (AAPC) and joinpoint regression.

resultsThe global age-standardized incidence of hepatitis B in children and adolescents decreased from 1385.20 per 100,000 population in 1990 to 418.68 per 100,000 population in 2021, with an AAPC of -3.76%. Similarly, age-standardized DALYs decreased from 70.78 per 100,000 population to 36.31 per 100,000 population, with an AAPC of -2.13%. The age-standardized prevalence (AAPC - 3.53%) and mortality (AAPC - 2.09%) of hepatitis B also decreased significantly. From 1990 to 2021, the age-standardized incidence and prevalence among males exhibited a higher trend compared to females, although both declined over time. These two indicators also decreased across all age subgroups, with consistently higher rates observed in the 15-19 age group compared to other age groups. The burden of hepatitis B demonstrated a notable reduction in countries with high-middle SDI, while it was highest in countries with low SDI. In 2021, Central sub-Saharan Africa and West sub-Saharan Africa reported the highest age-standardized incidence. For age-standardized DALYs, South Asia was the only region to experience an increase (AAPC 1.09%), while East Asia showed the largest decline (AAPC - 7.58%). Alcohol and drug use remained important risk factors for DALYs among people aged 15-19 years. Furthermore, the impact of drug use on disease burden was increasing, particularly in high-SDI countries.

conclusionsThe global burden and trends of hepatitis B decreased significantly in children and adolescents, exhibiting regional and national variations. Management of alcohol and drug use remains a major challenge for people aged 15-19 years.

Indexed as

Disability-Adjusted Life YearsGlobal Burden of DiseaseGlobal HealthHepatitis BAdolescentChildChild, PreschoolCost of IllnessFemaleHumansIncidenceInfantInfant, NewbornMalePrevalenceYoung AdultDisability-adjusted life yearsEpidemiologyGlobal burden of DiseaseHepatitis B virusIncidenceTrend

Identifiers

PMID39443929
PMCPMC11515762

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.