ArticleBMC public health2024
Association between healthy lifestyle on life course and multimorbidity in adults: results from two national prospective cohort studies.
Article in BMC public health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed.
- The Association of Diet and Lifestyle Factors With Quality of Life and Self-Rated Health in Older Adults: The Loma Linda Longevity Study.American journal of lifestyle medicine · 2026Article
- Associations between baseline level and clinical, anthropometric and behavioral changes in adults and the elderly diagnosed with hypertension and/or diabetes: a prospective cohort study.BMC public health · 2026Article
- Article
- Dynamic cross-lagged effects between healthy lifestyles and multimorbidity among middle-aged and older adults in China.BMC public health · 2025Article
- Association between adherence to cancer primary prevention recommendations and multimorbidity among a cohort of British Columbians.Journal of multimorbidity and comorbidityArticle
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
objectivesTo examine the correlation between healthy lifestyle patterns, their change trajectories, and the risk of multimorbidity in adults.
methodsBased on two representative national cohorts, the English Longitudinal Study of Aging (ELSA) and the Health and Retirement Study (HRS) including adults aged 50 years and over. We employed Cox regression, lifestyle change trajectories, and restricted mean survival times to explore the relationship between lifestyle (assessed by SCORE2, LE'8, and HLS scores) and multimorbidity. We also conducted mediation analysis to investigate the underlying mechanisms.
resultsA healthy lifestyle (higher LE'8, higher HLS, or lower SCORE2) can reduce the risk of multimorbidity. 2-10% lower multimorbidity risk per one-point increase in LE'8 and HLS. The hazard ratio of multimorbidity for improvements in unhealthy lifestyles or deterioration in healthy lifestyles compared to always healthy lifestyles ranged from 1.598 to 5.602. Besides, for LE'8 and HLS, participants with higher scores had a slower decrease in survival probability in ELSA. Triglyceride, C-reaction protein, fibrinogen, and cystatin C partly mediate the association between lifestyle and multimorbidity.
conclusionsKeeping a healthy lifestyle over time can help reduce the risk of multimorbidity.
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Registered trials
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