ArticleNature2024
Chromatin remodelling drives immune cell-fibroblast communication in heart failure.
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Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers.
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85citing papers in PubMed
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Who cites it
85 citing papers in PubMed.
- A human single-cell atlas identifies OLR1Nature genetics · 2026Article
- Cell Type-Specific Roles for BRD4 in Heart Failure.Current cardiology reports · 2026Review
- BRD4: From molecular understanding to therapeutics development.Molecular cell · 2026Review
- Macrophage PARP7 Alleviates Septic Cardiomyopathy by Interacting With TBK1 and Suppressing TBK1-Driven Inflammatory Response.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Cardiac immunity and heart repair: Mechanism, challenge, and future direction.Chinese medical journal · 2026Review
- Review
- Selective expansion of cardiac macrophage subtypes distinguishes their functional roles in disease and homeostasis.The Journal of clinical investigation · 2026Article
- Toll-like receptor 7 constrains efferocytosis in myocardial injury.Basic research in cardiology · 2026Article
- IL-1-Activated Inflammatory Cardiac Fibroblasts Exacerbate Acute Coxsackievirus B3 Myocarditis.JACC. Basic to translational science · 2026Article
- Cross-species functional transcriptomic analysis distinguishes conserved aging-niche remodeling from inflammatory fibroblast heterogeneity in cardiac aging and heart failure.Functional & integrative genomics · 2026Article
- SOX5 Orchestrates Malignant Evolution via Promoter-Centric Chromatin Remodeling in MYC-Driven B-Cell Lymphoma.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Targeting bromodomain and extraterminal proteins in cardiovascular disease: Pathological mechanisms and therapeutic applications.The Journal of international medical research · 2026Review
- Network pharmacology and experimental evaluation of Sanwei Tanxiang Tangsan in doxorubicin-induced heart failure.Journal of cardiothoracic surgery · 2026Article
- Ferroptosis-driven immune remodeling in heart failure: the central role of macrophage reprogramming and impaired efferocytosis.Journal of nanobiotechnology · 2026Review
- Epigenetically controlled endothelial promyelocytic leukemia drives liver inflammation and fibrosis.The Journal of clinical investigation · 2026Article
- TAK1 drives inflammatory fibroblast acquisition and shapes myocardial infarction responses in male mice.Nature communications · 2026Article
- Cardiac epigenome in heart development and disease.Nature reviews. Cardiology · 2026Review
- Hospital-treated infectious diseases and polygenic susceptibility in relation to heart failure and cardiac remodelling: evidence from the UK Biobank and ARIC cohorts.European heart journal open · 2026Article
- The impact of inflammation, neuromodulation, and gut microbiota on developing cardiac fibrosis and hypertension.Cardiovascular research · 2026Review
- Structural immunity: immune cells as architects of tissue barriers.Nature reviews. Immunology · 2026Review
25 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
30 authors.
Michael Alexanian *Gladstone Institutes, San Francisco, CA, USA. michael.alexanian@gladstone.ucsf.edu.ORCID 0000-0001-6224-6354
Arun Padmanabhan *Gladstone Institutes, San Francisco, CA, USA.
Tomohiro NishinoGladstone Institutes, San Francisco, CA, USA.ORCID 0000-0002-3593-7368
Joshua G TraversDepartment of Medicine, Division of Cardiology and Consortium for Fibrosis Research & Translation, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.ORCID 0000-0002-5660-2620
Lin YeGladstone Institutes, San Francisco, CA, USA.ORCID 0000-0001-7351-8685
Angelo PeloneroGladstone Institutes, San Francisco, CA, USA.
Clara Youngna LeeGladstone Institutes, San Francisco, CA, USA.ORCID 0000-0002-9402-4155
Nandhini SadagopanGladstone Institutes, San Francisco, CA, USA.
Yu HuangGladstone Institutes, San Francisco, CA, USA.
Kirsten AuclairGladstone Institutes, San Francisco, CA, USA.
Ada ZhuGladstone Institutes, San Francisco, CA, USA.
Yuqian AnGladstone Institutes, San Francisco, CA, USA.
Christina A EkstrandCoLabs initiative, University of California, San Francisco, CA, USA.ORCID 0009-0004-5182-3573
Cassandra MartinezGladstone Institutes, San Francisco, CA, USA.
Barbara Gonzalez TeranGladstone Institutes, San Francisco, CA, USA.
Will R FlaniganGladstone Institutes, San Francisco, CA, USA.ORCID 0000-0001-5900-3490
Charis Kee-Seon KimGladstone Institutes, San Francisco, CA, USA.ORCID 0000-0002-8344-7865
Koya Lumbao-ConradsonDepartment of Medicine, Division of Cardiology and Consortium for Fibrosis Research & Translation, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Zachary GardnerCardiovascular Institute, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0003-1905-8686
Li LiCardiovascular Institute, University of Pennsylvania, Philadelphia, PA, USA.
Mauro W CostaGladstone Institutes, San Francisco, CA, USA.ORCID 0000-0003-3579-8625
Rajan JainCardiovascular Institute, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0002-1979-044X
Israel CharoGladstone Institutes, San Francisco, CA, USA.
Alexis J CombesCoLabs initiative, University of California, San Francisco, CA, USA.ORCID 0000-0002-9110-6542
Saptarsi M HaldarGladstone Institutes, San Francisco, CA, USA.
Katherine S PollardGladstone Institutes, San Francisco, CA, USA.
Ronald J VagnozziDepartment of Medicine, Division of Cardiology and Consortium for Fibrosis Research & Translation, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.ORCID 0000-0002-8027-1809
Timothy A McKinseyDepartment of Medicine, Division of Cardiology and Consortium for Fibrosis Research & Translation, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Pawel F PrzytyckiGladstone Institutes, San Francisco, CA, USA.ORCID 0000-0002-3360-6936
Deepak SrivastavaGladstone Institutes, San Francisco, CA, USA.
Funding
Transcriptional Networks During Cardiac DifferentiationP01HL089707 · NHLBI · J. DAVID GLADSTONE INSTITUTES · PI SRIVASTAVA, DEEPAK · 2008 to 2017
$20.4MCARDIOGENESIS--MOLECULAR MECHANISMSR01HL057181 · NHLBI · UNIVERSITY OF TEXAS SW MED CTR/DALLAS · PI DEEPAK SRIVASTAVA · 1997 to 2026
$14.0MProject 3: Control of cardiac transcription by MEF2 and myocardinP01HL146366 · NHLBI · J. DAVID GLADSTONE INSTITUTES · PI SRIVASTAVA, DEEPAK · 2019 to 2023
$13.7MThe Epigenetic Landscape of Heart DevelopmentU01HL098179 · NHLBI · J. DAVID GLADSTONE INSTITUTES · PI BOYER, LAURIE A, BRUNEAU, BENOIT GAETAN · 2009 to 2014
$10.0MRegulation of Chromatin Signaling in Heart Failure by the BRD4 Bromodomain Protein.R01HL127240 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI MCKINSEY, TIMOTHY, SRIVASTAVA, DEEPAK · 2015 to 2022
$6.4MDeciphering how 3D genome organization orchestrates cardiac cellular identityR35HL166663 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI Rajan Jain · 2023 to 2026
$3.5MDeacetylase-Dependent Control of Diastolic Dysfunction and HFpEFR01HL147558 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI HOUSER, STEVEN R, MCKINSEY, TIMOTHY · 2019 to 2022
$3.1MRegulation of Cardiac Signaling by Class I Histone DeacetylasesR01HL116848 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI MCKINSEY, TIMOTHY · 2013 to 2021
$3.1MSmall molecule therapies targeting chromatin architecture in heart failureR01HL150225 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MCKINSEY, TIMOTHY, VONDRISKA, THOMAS M. · 2020 to 2023
$2.9MAortic Valve Disease: Mechanisms and Therapeutic ApproachesR01HL150100 · NHLBI · J. DAVID GLADSTONE INSTITUTES · PI SRIVASTAVA, DEEPAK · 2020 to 2023
$2.7MScreening and Development of Small Molecule HDAC11 Inhibitors to Treat Obesity and Diabetes.R01DK119594 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI LIN, HENING, MCKINSEY, TIMOTHY · 2019 to 2022
$2.1MMechanisms of Cardiac Injury Resolution by CX3CR1+ MacrophagesR01HL169578 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI Ronald Joseph Vagnozzi · 2023 to 2026
$1.7MAHRQ HHS R01 HS015100NHLBI NIH HHS K08 HL157700NHLBI NIH HHS K99 HL166708NHLBI NIH HHS P01 HL089707NHLBI NIH HHS P01 HL146366NHLBI NIH HHS R01 HL057181NHLBI NIH HHS R01 HL116848NHLBI NIH HHS R01 HL127240NHLBI NIH HHS R01 HL147558NHLBI NIH HHS R01 HL150100NHLBI NIH HHS R01 HL150225NHLBI NIH HHS R01 HL169578NHLBI NIH HHS R35 HL166663NHLBI NIH HHS U01 HL098179NIDDK NIH HHS R01 DK119594
Abstract
Chronic inflammation and tissue fibrosis are common responses that worsen organ function, yet the molecular mechanisms governing their cross-talk are poorly understood. In diseased organs, stress-induced gene expression changes fuel maladaptive cell state transitions
Indexed as
Cell CommunicationChromatinChromatin Assembly and DisassemblyFibroblastsHeart FailureAnimalsBromodomain Containing ProteinsCell Cycle ProteinsCX3C Chemokine Receptor 1Enhancer Elements, GeneticFemaleFibrosisHomeodomain ProteinsHumansInterleukin-1betaMacrophagesBRD4 protein, humanBrd4 protein, mouseBromodomain Containing ProteinsCell Cycle ProteinsChromatinCX3C Chemokine Receptor 1Cx3cr1 protein, mouseHomeodomain ProteinsIL1B protein, humanIL1B protein, mouseInterleukin-1betaMEOX1 protein, humanMeox1 protein, mouseNuclear ProteinsRELA protein, humanRela protein, mouseTranscription Factor RelATranscription Factors
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.