Evidence map›Paper›PMID 39443796›Full record

ArticleNature2024

Nuclear release of eIF1 restricts start-codon selection during mitosis.

Jimmy Ly, Kehui Xiang, Kuan-Chung Su, Gunter B Sissoko, David P Bartel, Iain M Cheeseman

Abstract read
In one paragraph

Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed.

  1. Functional analysis ofMolecular therapy. Nucleic acids · 2026
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  20. When the Clock Is Ticking: The Role of Mitotic Duration in Cell Fate Determination.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Jimmy LyWhitehead Institute for Biomedical Research, Cambridge, MA, USA.ORCID 0009-0004-8585-9347
Kehui XiangWhitehead Institute for Biomedical Research, Cambridge, MA, USA.ORCID 0000-0002-3770-1367
Kuan-Chung SuWhitehead Institute for Biomedical Research, Cambridge, MA, USA.ORCID 0000-0002-0787-0071
Gunter B SissokoWhitehead Institute for Biomedical Research, Cambridge, MA, USA.ORCID 0000-0003-4665-9305
David P BartelWhitehead Institute for Biomedical Research, Cambridge, MA, USA.ORCID 0000-0002-3872-2856
Iain M CheesemanWhitehead Institute for Biomedical Research, Cambridge, MA, USA. icheese@wi.mit.edu.ORCID 0000-0002-3829-5612

Funding

Molecular Analysis of Kinetochore FunctionR35GM126930 · NIGMS · WHITEHEAD INSTITUTE FOR BIOMEDICAL RES · PI Iain McPherson Cheeseman · 2018 to 2026
$7.0M
NIGMS NIH HHS R35 GM126930
6 · The paper itself

Abstract

Regulated start-codon selection has the potential to reshape the proteome through the differential production of upstream open reading frames, canonical proteins, and alternative translational isoforms

Indexed as

Cell NucleusCodon, InitiatorEukaryotic Initiation Factor-1MitosisAnimalsCell DeathEukaryotic Initiation FactorsFemaleHumansMiceNeoplasm ProteinsNerve Tissue ProteinsNuclear EnvelopePeptide Chain Initiation, TranslationalProtein BiosynthesisProtein IsoformsCodon, InitiatorEIF1 protein, humanEukaryotic Initiation Factor-1Eukaryotic Initiation FactorsNeoplasm ProteinsNerve Tissue ProteinsProtein Isoforms

Identifiers

PMID39443796
PMCPMC11605796

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.