ArticleNature2024
Targeting immune-fibroblast cell communication in heart failure.
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In one paragraph
Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 194 papers, 3 of them syntheses that pooled it.
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0cells of the map it votes in
194citing papers in PubMed, 3 pooled it
–field-weighted citation impact
What it found
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The trial behind it
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Who cites it
194 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Immunology of heart failure with preserved ejection fraction.Expert review of clinical immunology · 2025Pooled it
- Genomic data-driven framework for drug target discovery in atrial fibrillation.Journal of translational medicine · 2025Pooled it
- Chemotherapy cardiotoxicity research in cancer patients: a bibliometric and visual analysis (1994-2024).Frontiers in oncology · 2025Pooled it
- A human single-cell atlas identifies OLR1Nature genetics · 2026Article
- Reconstructing AF-associated atrial fibrosis: Patient-specific iPSC models, fit-for-purpose atrial microphysiological systems, and nanomedicine.Materials today. Bio · 2026Review
- Endothelial PARP1 orchestrates endothelial-to-mesenchymal transition via the PARylation of FHL2 in ischaemic heart failure.Acta pharmacologica Sinica · 2026Article
- MMP12 induces fibrogenic macrophage differentiation to drive granuloma-associated cardiac fibrosis.American journal of respiratory and critical care medicine · 2026Article
- Cell Type-Specific Roles for BRD4 in Heart Failure.Current cardiology reports · 2026Review
- Cardiac proteomic and phosphoproteomic profiling defines clinically relevant molecular subgroups in human heart failure.Nature cardiovascular research · 2026Article
- Fibroblast Growth Factor 23 and Outcomes in Acute Heart Failure.Biomolecules · 2026Article
- Cardiac fibrosis: mechanistic insights and translational advances.Molecular biomedicine · 2026Review
- Periostin-CCL3 Feedforward Signaling Loop Promotes Cardiac Fibrosis and Cardiomyocyte Necroptosis in Arrhythmogenic Cardiomyopathy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Human pericardial macrophages suppress cardiac fibrosis through cystatin C signaling after myocardial infarction.JCI insight · 2026Article
- Macrophage heterogeneity in organ fibrosis in the era of single-cell omics.Molecular biology reports · 2026Review
- Dynamic cellular programs of human cardiac allograft rejection revealed by spatial transcriptomics.Nature cardiovascular research · 2026Article
- Cellular Remodeling of Skeletal Muscle Following Botulinum Toxin A Injection: A Single-Nucleus RNA Sequencing Study.Aesthetic plastic surgery · 2026Article
- Bioinformatics Analysis and Experimental Validation of Key Genes Associated With Hypoxia and Ischemia in Myocardial Infarction.Molecular genetics & genomic medicine · 2026Article
- Reversing the pipeline: a 'human-first' multi-omics approach to cardiovascular discovery.Experimental & molecular medicine · 2026Review
- Article
- Genetics-Informed Mapping Identifies a CRIM1-Associated Endocardial Inflammatory Remodeling State in Acute Myocardial Infarction.Medical science monitor : international medical journal of experimental and clinical research · 2026Article
134 more citing papers are in PubMed but not listed here.
Corrections and comments
- Update of
Authors and funding
36 authors.
Junedh M Amrute *Center for Cardiovascular Research, Division of Cardiology, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA.ORCID 0000-0002-6851-0168
Xin Luo *Amgen Discovery Research, Amgen Inc., South San Francisco, CA, USA.
Vinay PennaCenter for Cardiovascular Research, Division of Cardiology, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA.
Steven YangCenter for Cardiovascular Research, Division of Cardiology, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA.
Tracy YamawakiAmgen Discovery Research, Amgen Inc., South San Francisco, CA, USA.ORCID 0000-0002-7716-5650
Sikander HayatInstitute of Experimental Medicine and Systems Biology, Faculty of Medicine, RWTH Aachen University, Aachen, Germany.ORCID 0000-0001-5919-8371
Andrea BredemeyerCenter for Cardiovascular Research, Division of Cardiology, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA.ORCID 0000-0003-2970-5998
In-Hyuk JungCenter for Cardiovascular Research, Division of Cardiology, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA.ORCID 0000-0002-9469-9590
Farid F KadyrovCenter for Cardiovascular Research, Division of Cardiology, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA.
Gyu Seong HeoMallinckrodt Institute of Radiology, Washington University School of Medicine, Saint Louis, MO, USA.
Rajiu VenkatesanMallinckrodt Institute of Radiology, Washington University School of Medicine, Saint Louis, MO, USA.
Sally Yu ShiAmgen Discovery Research, Amgen Inc., South San Francisco, CA, USA.
Alekhya ParvathaneniCenter for Cardiovascular Research, Division of Cardiology, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA.ORCID 0000-0002-2976-1941
Andrew L KoenigCenter for Cardiovascular Research, Division of Cardiology, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA.ORCID 0000-0003-4384-1267
Christoph KuppeInstitute of Experimental Medicine and Systems Biology, Faculty of Medicine, RWTH Aachen University, Aachen, Germany.ORCID 0000-0003-4597-9833
Candice BakerJackson Laboratory, Bar Harbor, ME, USA.ORCID 0009-0008-7793-3008
Hannah LuehmannMallinckrodt Institute of Radiology, Washington University School of Medicine, Saint Louis, MO, USA.ORCID 0000-0002-7516-6772
Cameran JonesCenter for Cardiovascular Research, Division of Cardiology, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA.
Benjamin KopeckyCenter for Cardiovascular Research, Division of Cardiology, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA.ORCID 0000-0002-9087-6254
Xue ZengAmgen Discovery Research, Amgen Inc., South San Francisco, CA, USA.
Tore BleckwehlInstitute of Experimental Medicine and Systems Biology, Faculty of Medicine, RWTH Aachen University, Aachen, Germany.ORCID 0000-0003-1116-0512
Pan MaCenter for Cardiovascular Research, Division of Cardiology, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA.
Paul LeeCenter for Cardiovascular Research, Division of Cardiology, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA.
Yuriko TeradaDivision of Cardiothoracic Surgery, Department of Surgery, Washington University School of Medicine, Saint Louis, MO, USA.
Angela FuAmgen Discovery Research, Amgen Inc., South San Francisco, CA, USA.
Milena FurtadoAmgen Discovery Research, Amgen Inc., South San Francisco, CA, USA.
Daniel KreiselDivision of Cardiothoracic Surgery, Department of Surgery, Washington University School of Medicine, Saint Louis, MO, USA.
Atilla KovacsCenter for Cardiovascular Research, Division of Cardiology, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA.
Nathan O StitzielCenter for Cardiovascular Research, Division of Cardiology, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA.ORCID 0000-0002-4963-8211
Simon JacksonAmgen Discovery Research, Amgen Inc., South San Francisco, CA, USA.
Chi-Ming LiAmgen Discovery Research, Amgen Inc., South San Francisco, CA, USA.
Yongjian LiuMallinckrodt Institute of Radiology, Washington University School of Medicine, Saint Louis, MO, USA.ORCID 0000-0002-1118-1535
Nadia A RosenthalJackson Laboratory, Bar Harbor, ME, USA.ORCID 0000-0002-7599-7365
Rafael KramannInstitute of Experimental Medicine and Systems Biology, Faculty of Medicine, RWTH Aachen University, Aachen, Germany.
Brandon AsonAmgen Discovery Research, Amgen Inc., South San Francisco, CA, USA.
Kory J LavineCenter for Cardiovascular Research, Division of Cardiology, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA. klavine@wustl.edu.ORCID 0000-0003-1948-9945
Funding
Washington University Center for Cellular ImagingP30CA091842 · NCI · WASHINGTON UNIVERSITY · PI AIMEE S JAMES · 2001 to 2026
$128.0MNATIONAL RESEARCH SERVICE AWARD-MEDICAL SCIENTISTT32GM007200 · NIGMS · WASHINGTON UNIVERSITY · PI YOKOYAMA, WAYNE M. · 1985 to 2024
$59.8MTraining/DisseminationP41EB025815 · NIBIB · WASHINGTON UNIVERSITY · PI Buck E. Rogers · 2018 to 2026
$12.7MWashington University Rheumatic DiseasesResearch Resource-based CenterP30AR073752 · NIAMS · WASHINGTON UNIVERSITY · PI Christine T. Pham · 2018 to 2026
$7.6MTargeted Molecular Probes for Atherosclerosis Imaging and TherapyR35HL145212 · NHLBI · WASHINGTON UNIVERSITY · PI LIU, YONGJIAN · 2019 to 2025
$5.1MSpecification and Function of Tissue Resident and Recruited Macrophages in Cardiac Remodeling and Heart FailureR35HL161185 · NHLBI · WASHINGTON UNIVERSITY · PI Kory J. Lavine · 2022 to 2026
$4.3MThe Role of Donor Innate Immune Responses in Regulating Alloimmunity after Heart TransplantationR01HL151078 · NHLBI · WASHINGTON UNIVERSITY · PI KREISEL, DANIEL, LAVINE, KORY J. · 2020 to 2023
$2.6MMACROPHAGE HETEROGENEITY IN HEART FAILURE PROGRESSION AND CARDIAC RECOVERYR01HL138466 · NHLBI · WASHINGTON UNIVERSITY · PI LAVINE, KORY J. · 2017 to 2021
$1.9MMACROPHAGE ONTOGENY SHIFTS IN ISCHEMIC HEART DISEASER01HL139714 · NHLBI · WASHINGTON UNIVERSITY · PI LAVINE, KORY J. · 2018 to 2021
$1.5MHIGH-RESOLUTON ULTRASOUND SYSTEM FOR PHENOTYPIC EVALUATION OF THE CARDIOVASCULAR SYSTEM IN MICES10OD028597 · OD · WASHINGTON UNIVERSITY · PI KOVACS, ATTILA · 2020 to 2020
$378kNCI NIH HHS P30 CA091842NHLBI NIH HHS R01 HL138466NHLBI NIH HHS R01 HL139714NHLBI NIH HHS R01 HL151078NHLBI NIH HHS R35 HL145212NHLBI NIH HHS R35 HL161185NIAMS NIH HHS P30 AR073752NIBIB NIH HHS P41 EB025815NIGMS NIH HHS T32 GM007200NIH HHS S10 OD028597
Abstract
Inflammation and tissue fibrosis co-exist and are causally linked to organ dysfunction
Indexed as
Cell CommunicationFibroblastsHeart FailureAnimalsCell Adhesion MoleculesCell LineageChromatinDisease Models, AnimalEndopeptidasesEpitope MappingFemaleFibroblast Activation Protein AlphaFibrosisHumansInterleukin-1betaMacrophagesCCR2 protein, humanCcr2 protein, mouseCell Adhesion MoleculesChromatinEndopeptidasesFibroblast Activation Protein AlphaIL1B protein, humanIL1B protein, mouseInterleukin-1betaMembrane ProteinsPOSTN protein, humanPostn protein, mouseReceptors, CCR2Serine Endopeptidases
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.