ArticleNature2024
The importance of family-based sampling for biobanks.
Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed.
- Phenomic profiles and disease patterns of 1.9 million participants from Our Future Health.Nature medicine · 2026Article
- Article
- Genetic architectures of brain-related traits are shaped by strong selective constraints.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Article
- A generalized test of genotype-phenotype causality in population-sampled nuclear families.PLoS genetics · 2026Article
- From Nuisance to Signal: Leveraging Close Relatives in Biobank-Scale Demographic Inference.bioRxiv : the preprint server for biology · 2026Article
- [Association analysis between genetic nurturing effects ofBeijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2026Article
- Evaluating confounding in rare variant genome wide association studies.Nature communications · 2026Article
- Challenges and future directions for Mendelian randomization.Nature genetics · 2026Review
- Genetic architectures of brain-related traits are shaped by strong selective constraints.bioRxiv : the preprint server for biology · 2026Article
- Advancing Life Sciences and Biotechnology in Saudi Arabia: A Comprehensive Overview of the Saudi Biobank Project Study Design and Aspirations.Journal of epidemiology and global health · 2026Review
- Imputing Parental Genotypes Through Mendelian Imputation: Ethical and Legal Considerations.Behavior genetics · 2026Review
- Mendelian Randomization Methods for Causal Inference: Estimands, Identification and Inference.Statistics in medicine · 2026Review
- Mexico City Prospective Study: cohort profile update.BMJ medicine · 2026Article
- Genetic effects on migration behavior contribute to increasing spatial differentiation at trait-associated loci in Estonia.iScience · 2025Article
- An Updated Polygenic Index Repository: Expanded Phenotypes, New Cohorts, and Improved Causal Inference.Research square · 2025Article
- Realizing the full potential of Our Future Health through data linkage and trans-biobank efforts.Nature genetics · 2025Article
- Article
- Cohort Profile Update: The Norwegian Mother, Father and Child Cohort (MoBa).International journal of epidemiology · 2025Article
- An Updated Polygenic Index Repository: Expanded Phenotypes, New Cohorts, and Improved Causal Inference.bioRxiv : the preprint server for biology · 2025Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Biobanks aim to improve our understanding of health and disease by collecting and analysing diverse biological and phenotypic information in large samples. So far, biobanks have largely pursued a population-based sampling strategy, where the individual is the unit of sampling, and familial relatedness occurs sporadically and by chance. This strategy has been remarkably efficient and successful, leading to thousands of scientific discoveries across multiple research domains, and plans for the next wave of biobanks are underway. In this Perspective, we discuss the strengths and limitations of a complementary sampling strategy for future biobanks based on oversampling of close genetic relatives. Such family-based samples facilitate research that clarifies causal relationships between putative risk factors and outcomes, particularly in estimates of genetic effects, because they enable analyses that reduce or eliminate confounding due to familial and demographic factors. Family-based biobank samples would also shed new light on fundamental questions across multiple fields that are often difficult to explore in population-based samples. Despite the potential for higher costs and greater analytical complexity, the many advantages of family-based samples should often outweigh their potential challenges.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.