ArticleNature communications2024
Sensory experience steers representational drift in mouse visual cortex.
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed.
- Synaptic Development of Fine Spatial Scale Organization of Neuronal Orientation Tuning in Mouse Primary Visual Cortex.bioRxiv : the preprint server for biology · 2026Article
- Changes in perceptual sampling contribute to representational drift.bioRxiv : the preprint server for biology · 2026Article
- Article
- Coordinated Representational Drift Across the Mouse Cortex.Research square · 2026Article
- Coordinated Representational Drift Across the Mouse Cortex.bioRxiv : the preprint server for biology · 2026Article
- Learning shapes neural codes for sensory-motor integration in the tail of the striatum.bioRxiv : the preprint server for biology · 2026Article
- CRISPR inhibition of activity-dependent Arc expression in the adult mouse brain has limited effects on plasticity in visual cortex and nucleus accumbens.bioRxiv : the preprint server for biology · 2026Article
- Months-long stability of the head-direction system.Nature · 2026Article
- Representational drift reflects ongoing balancing of stochastic changes by Hebbian learning.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- How the olfactory bulb maintains stable odor manifolds amid adaptation and representational drift.bioRxiv : the preprint server for biology · 2026Article
- Temporal coding carries more stable cortical visual representations than firing rate over time.Nature communications · 2025Article
- Wider Than the Sky: An Alternative to "Mapping" the World Onto the Brain.The European journal of neuroscience · 2025Article
- Representational drift without synaptic plasticity.bioRxiv : the preprint server for biology · 2025Article
- Homeostasis of a representational map in the neocortex.Nature neuroscience · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
Representational drift-the gradual continuous change of neuronal representations-has been observed across many brain areas. It is unclear whether drift is caused by synaptic plasticity elicited by sensory experience, or by the intrinsic volatility of synapses. Here, using chronic two-photon calcium imaging in primary visual cortex of female mice, we find that the preferred stimulus orientation of individual neurons slowly drifts over the course of weeks. By using cylinder lens goggles to limit visual experience to a narrow range of orientations, we show that the direction of drift, but not its magnitude, is biased by the statistics of visual input. A network model suggests that drift of preferred orientation largely results from synaptic volatility, which under normal visual conditions is counteracted by experience-driven Hebbian mechanisms, stabilizing preferred orientation. Under deprivation conditions these Hebbian mechanisms enable adaptation. Thus, Hebbian synaptic plasticity steers drift to match the statistics of the environment.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.