Evidence map›Paper›PMID 39443481›Full record

ArticleCell death & disease2024

Enhanced mGluR

Ana Toledano-Zaragoza, Violeta Enriquez-Zarralanga, Sara Naya-Forcano, Víctor Briz, Rocío Alfaro-Ruíz, Miguel Parra-Martínez, Daniel N Mitroi, Rafael Luján, José A Esteban, María Dolores Ledesma

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell death & disease, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Modulation of glutamate metabolism in Niemann-pick disease type C1 mice.Molecular genetics and metabolism reports · 2026
    Article
  2. Review
  3. Review
  4. A New GlyT2 Variant Associated with Hyperekplexia.International journal of molecular sciences · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ana Toledano-Zaragoza *Centro Biología Molecular Severo Ochoa (CSIC-UAM), Madrid, Spain.ORCID 0000-0002-9311-6226
Violeta Enriquez-Zarralanga *Centro Biología Molecular Severo Ochoa (CSIC-UAM), Madrid, Spain.
Sara Naya-ForcanoCentro Biología Molecular Severo Ochoa (CSIC-UAM), Madrid, Spain.
Víctor BrizCentro Biología Molecular Severo Ochoa (CSIC-UAM), Madrid, Spain.ORCID 0000-0001-6936-0918
Rocío Alfaro-RuízSynaptic Structure Laboratory, Instituto de Investigación en Discapacidades Neurológicas (IDINE), Facultad de Medicina, Universidad de Castilla-La Mancha, Albacete, Spain.
Miguel Parra-MartínezCentro Biología Molecular Severo Ochoa (CSIC-UAM), Madrid, Spain.
Daniel N MitroiCentro Biología Molecular Severo Ochoa (CSIC-UAM), Madrid, Spain.
Rafael LujánSynaptic Structure Laboratory, Instituto de Investigación en Discapacidades Neurológicas (IDINE), Facultad de Medicina, Universidad de Castilla-La Mancha, Albacete, Spain.
José A EstebanCentro Biología Molecular Severo Ochoa (CSIC-UAM), Madrid, Spain.
María Dolores LedesmaCentro Biología Molecular Severo Ochoa (CSIC-UAM), Madrid, Spain. dledesma@cbm.csic.es.ORCID 0000-0002-5679-6891

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Niemann-Pick disease Type C (NPC) is caused by mutations in the cholesterol transport protein NPC1 leading to the endolysosomal accumulation of the lipid and to psychiatric alterations. Using an NPC mouse model (Npc1

Indexed as

NeuronsNiemann-Pick C1 ProteinNiemann-Pick Disease, Type CReceptor, Metabotropic Glutamate 5AnimalsCholesterolDisease Models, AnimalHippocampusHumansImidazolesIntracellular Signaling Peptides and ProteinsLong-Term Synaptic DepressionLysosomesMicePyridines2-chloro-4-((2,5-dimethyl-1-(4-(trifluoromethoxy)phenyl)-1H-imidazol-4-yl)ethynyl)pyridineCholesterolGrm5 protein, mouseImidazolesIntracellular Signaling Peptides and ProteinsNiemann-Pick C1 ProteinNpc1 protein, mousePyridinesReceptor, Metabotropic Glutamate 5

Identifiers

PMID39443481
PMCPMC11499878

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.