Evidence map›Paper›PMID 39443396›Full record

ArticleJournal of natural medicines2025

Methoxyflavone glucosides and caffeoyl phenylethanoid glycoside from Lysionotus pauciflorus: their structures and anti-ferroptosis activity.

Rena Takizawa, Tomoyo Minamizono, Daisuke Tsuji, Xiao-Jie Yan, Feng-Lai Lu, Xue-Rong Yang, Dian-Peng Li, Reiko Akagi, Yoshiki Kashiwada, Naonobu Tanaka

Abstract read
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In one paragraph

Article in Journal of natural medicines, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Rena Takizawa *Graduate School of Pharmaceutical Sciences, Tokushima University, Tokushima, 770-8505, Japan.
Tomoyo Minamizono *Graduate School of Pharmaceutical Sciences, Tokushima University, Tokushima, 770-8505, Japan.
Daisuke TsujiFaculty of Pharmacy, Yasuda Women's University, Hiroshima, 731-0153, Japan.
Xiao-Jie YanGuangxi Key Laboratory of Plant Functional Phytochemicals and Sustainable Utilization, Guangxi Institute of Botany, Guangxi Zhuang Autonomous Region and Chinese Academy of Sciences, Guilin, 541006, China.
Feng-Lai LuGuangxi Key Laboratory of Plant Functional Phytochemicals and Sustainable Utilization, Guangxi Institute of Botany, Guangxi Zhuang Autonomous Region and Chinese Academy of Sciences, Guilin, 541006, China.
Xue-Rong YangGuangxi Key Laboratory of Plant Functional Phytochemicals and Sustainable Utilization, Guangxi Institute of Botany, Guangxi Zhuang Autonomous Region and Chinese Academy of Sciences, Guilin, 541006, China.
Dian-Peng LiEngineering Research Center of Innovative Traditional Chinese, Zhuang and Yao Materia Medica, Ministry of Education, Guangxi University of Chinese Medicine, Nanning, 530200, China.
Reiko AkagiFaculty of Pharmacy, Yasuda Women's University, Hiroshima, 731-0153, Japan.
Yoshiki KashiwadaGraduate School of Pharmaceutical Sciences, Tokushima University, Tokushima, 770-8505, Japan.
Naonobu TanakaGraduate School of Pharmaceutical Sciences, Tokushima University, Tokushima, 770-8505, Japan. ntanak@tokushima-u.ac.jp.ORCID http://orcid.org/0000-0002-9281-7098

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Phytochemical investigation on the aerial parts of Lysionotus pauciflorus Maxim. (Gesneriaceae), a medicinal plant used in Guangxi Zhuang Autonomous Region, China, resulted in the isolation of 13 secondary metabolites including two methoxyflavones, six flavonoid glycosides, and five caffeoyl phenylethanoid glycosides. Among these, the chemical structures of previously undescribed metabolites (1-3) were elucidated to be nevadensin 7-O-β-D-glucopyranosyl-(1 → 2)-β-D-glucopyranoside (1), nevadensin 7-O-β-D-glucopyranosyl-(1 → 6)-β-D-glucopyranoside (2), and 2-(3,4-dihydroxyphenyl)ethyl-1-O-β-D-apiofuranosyl-(1 → 4)-α-L-rhamnopyranosyl-(1 → 3)-β-D-(6'-O-E-caffeoyl)glucopyranoside (3) by detailed spectroscopic and HPLC analyses. Inhibitory activity of isolated compounds against RSL3-induced ferroptosis on human hepatoma Hep3B cells were evaluated.

Indexed as

FlavonoidsGlucosidesGlycosidesPlant ExtractsCell Line, TumorHumansMolecular StructureFlavonoidsGlucosidesGlycosidesPlant ExtractsAnti-ferroptosis activityCaffeoyl phenylethanoid glycosideLysionotus pauciflorusMethoxyflavone glucoside

Identifiers

PMID39443396

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.