Evidence map›Paper›PMID 39443386›Full record

Trial reportAnnals of nuclear medicine2025

Head-to-head comparison of

Masao Watanabe, Wolfgang P Fendler, Hong Grafe, Nader Hirmas, Rainer Hamacher, Helena Lanzafame, Kim M Pabst, Hubertus Hautzel, Clemens Aigner, Stefan Kasper and 11 more

2 registry-linked trialsAbstract readClinical Trial, Phase IIComparative StudyObservational Study
PubMed Publisher
In one paragraph

Trial report in Annals of nuclear medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04571086 recruitingnot on this map

68-Ga-FAPI-PET for Tumor Detection: A Prospective Observational Trial

Typeobservational_patient_registrySponsorUniversity Hospital, EssenRan2020 to 2027Enrolled500ConditionsMalignant Neoplasm
NCT05160051 phase2completednot on this map

68Ga-FAPI-46 PET for Imaging of FAP Expressing Cancer: A Single-center Prospective Interventional Single-arm Clinical Trial

TypeinterventionalSponsorUniversity Hospital, EssenRan2021 to 2024Enrolled158ConditionsTumor, SolidArms68Ga-FAPI-46 PET Scan
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. The Role ofMolecular imaging and radionuclide therapy · 2026
    Article
  3. Article
  4. Preclinical evaluation of novelAnnals of nuclear medicine · 2026
    Article
  5. Article
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Masao WatanabeDepartment of Nuclear Medicine, University Clinic Essen, Hufelandstr. 55, 45147, Essen, Germany. d7he4ng@gmail.com.ORCID http://orcid.org/0009-0002-7062-6773
Wolfgang P FendlerDepartment of Nuclear Medicine, University Clinic Essen, Hufelandstr. 55, 45147, Essen, Germany.
Hong GrafeDepartment of Nuclear Medicine, University Clinic Essen, Hufelandstr. 55, 45147, Essen, Germany.
Nader HirmasDepartment of Nuclear Medicine, University of Duisburg-Essen and German Cancer Consortium (DKTK)-University Hospital Essen, Hufelandstr. 55, 45147, Essen, Germany.
Rainer HamacherDepartment of Medical Oncology, West German Cancer Center, University of Duisburg-Essen and German Cancer Consortium (DKTK)-University Hospital Essen, Hufelandstr. 55, 45147, Essen, Germany.
Helena LanzafameDepartment of Nuclear Medicine, University of Duisburg-Essen and German Cancer Consortium (DKTK)-University Hospital Essen, Hufelandstr. 55, 45147, Essen, Germany.
Kim M PabstDepartment of Nuclear Medicine, University of Duisburg-Essen and German Cancer Consortium (DKTK)-University Hospital Essen, Hufelandstr. 55, 45147, Essen, Germany.
Hubertus HautzelDepartment of Nuclear Medicine, University Clinic Essen, Hufelandstr. 55, 45147, Essen, Germany.
Clemens AignerDepartment of Thoracic Surgery and Thoracic Endoscopy, University of Duisburg-Essen and German Cancer Consortium (DKTK)-University Hospital Essen, Essen, Germany.
Stefan KasperDepartment of Medical Oncology, West German Cancer Center, University of Duisburg-Essen and German Cancer Consortium (DKTK)-University Hospital Essen, Hufelandstr. 55, 45147, Essen, Germany.
Bastian von TresckowDepartment of Hematology and Stem Cell Transplantation, West German Cancer Center and German Cancer Consortium (DKTK Partner Site Essen), University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Martin StuschkeDepartment of Radiation Therapy, University of Duisburg-Essen and German Cancer Consortium (DKTK)-University Hospital Essen, Essen, Germany.
Sherko KümmelDepartment of Gynecology and Gynecologic Oncology, Ev. Kliniken Essen-Mitte (KEM), Essen, Germany.
Celine LugnierDepartment of Hematology and Oncology With Palliative Care, Ruhr-University Bochum, Bochum, Germany.
Boris HadaschikDepartment of Urology, Department for Medical Oncology, University of Duisburg-Essen and German Cancer Consortium (DKTK)-University Hospital Essen, Essen, Germany.
Viktor GrünwaldDepartment of Urology, Department for Medical Oncology, University of Duisburg-Essen and German Cancer Consortium (DKTK)-University Hospital Essen, Essen, Germany.
Fadi ZarradDepartment of Nuclear Medicine, University of Duisburg-Essen and German Cancer Consortium (DKTK)-University Hospital Essen, Hufelandstr. 55, 45147, Essen, Germany.
David KerstingDepartment of Nuclear Medicine, University Clinic Essen, Hufelandstr. 55, 45147, Essen, Germany.
Jens T SivekeBridge Institute of Experimental Tumor Therapy, West German Cancer Center, University Hospital Essen, Hufelandstr. 55, 45147, Essen, Germany.
Ken HerrmannDepartment of Nuclear Medicine, University Clinic Essen, Hufelandstr. 55, 45147, Essen, Germany.
Manuel WeberDepartment of Nuclear Medicine, University Clinic Essen, Hufelandstr. 55, 45147, Essen, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveFAPI-PET/CT exhibits high tumor uptake and low background accumulation, enabling high-sensitivity tumor detection. We compared the diagnostic performance of

methods232 patients underwent

resultsLesion-based detection rates in

conclusions

trial registrationA total of N = 232 patients were analyzed. Of these, N = 50 patients were included in a prospective interventional trial (NCT05160051), and N = 175 in a prospective observational trial (NCT04571086) for correlation and clinical follow-up of PET findings; N = 7 patients were analyzed retrospectively.

Indexed as

Contrast MediaCoordination ComplexesFluorodeoxyglucose F18NeoplasmsPositron Emission Tomography Computed TomographyTomography, X-Ray ComputedAdolescentAdultAgedAged, 80 and overFemaleGallium IsotopesGallium RadioisotopesHumansMaleMiddle Aged68Ga-FAPIContrast MediaCoordination ComplexesFluorodeoxyglucose F18Gallium IsotopesGallium RadioisotopesQuinolines18F-FDG68 Ga-FAPI-46Contrast-enhanced CTDetection ratePET/CT

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.