Evidence map›Paper›PMID 39443157›Full record

ArticleMolecular pharmacology2024

Mechanisms of Action Underlying Conductance-Modifying Positive Allosteric Modulators of the NMDA Receptor.

Elijah Z Ullman, Riley E Perszyk, Srinu Paladugu, Russell G Fritzemeier, Nicholas S Akins, Leon Jacobs, Dennis C Liotta, Stephen F Traynelis

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular pharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. The positive allosteric modulator GNE-9278 increases gating, conductance, and CaNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Elijah Z UllmanDepartments of Pharmacology and Chemical Biology, Emory School of Medicine (E.Z.U., R.E.P., S.F.T.) and Chemistry (S.P., R.G.F., N.S.A., L.J., D.C.L.), Emory University, Atlanta, Georgia.ORCID 0000-0002-6122-023X
Riley E PerszykDepartments of Pharmacology and Chemical Biology, Emory School of Medicine (E.Z.U., R.E.P., S.F.T.) and Chemistry (S.P., R.G.F., N.S.A., L.J., D.C.L.), Emory University, Atlanta, Georgia.ORCID 0000-0001-8283-7709
Srinu PaladuguDepartments of Pharmacology and Chemical Biology, Emory School of Medicine (E.Z.U., R.E.P., S.F.T.) and Chemistry (S.P., R.G.F., N.S.A., L.J., D.C.L.), Emory University, Atlanta, Georgia.
Russell G FritzemeierDepartments of Pharmacology and Chemical Biology, Emory School of Medicine (E.Z.U., R.E.P., S.F.T.) and Chemistry (S.P., R.G.F., N.S.A., L.J., D.C.L.), Emory University, Atlanta, Georgia.
Nicholas S AkinsDepartments of Pharmacology and Chemical Biology, Emory School of Medicine (E.Z.U., R.E.P., S.F.T.) and Chemistry (S.P., R.G.F., N.S.A., L.J., D.C.L.), Emory University, Atlanta, Georgia.
Leon JacobsDepartments of Pharmacology and Chemical Biology, Emory School of Medicine (E.Z.U., R.E.P., S.F.T.) and Chemistry (S.P., R.G.F., N.S.A., L.J., D.C.L.), Emory University, Atlanta, Georgia.
Dennis C LiottaDepartments of Pharmacology and Chemical Biology, Emory School of Medicine (E.Z.U., R.E.P., S.F.T.) and Chemistry (S.P., R.G.F., N.S.A., L.J., D.C.L.), Emory University, Atlanta, Georgia.ORCID 0000-0002-7736-7113
Stephen F TraynelisDepartments of Pharmacology and Chemical Biology, Emory School of Medicine (E.Z.U., R.E.P., S.F.T.) and Chemistry (S.P., R.G.F., N.S.A., L.J., D.C.L.), Emory University, Atlanta, Georgia strayne@emory.edu.ORCID 0000-0002-3750-9615

Funding

Glutamate receptors and human neurological diseaseR35NS111619 · NINDS · EMORY UNIVERSITY · PI Stephen F Traynelis · 2019 to 2026
$6.6M
NINDS NIH HHS R35 NS111619
6 · The paper itself

Abstract

N-methyl-D-aspartate receptors (NMDARs) are ionotropic glutamate receptors that mediate a slow, Ca

Indexed as

Receptors, N-Methyl-D-AspartateXenopus laevisAllosteric RegulationAnimalsFemaleGlutamic AcidGlycineHEK293 CellsHumansNeuronsOocytesPyrimidinesRatsGlutamic AcidGlycinePyrimidinesReceptors, N-Methyl-D-Aspartate

Identifiers

PMID39443157
PMCPMC11585258

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.