Evidence map›Paper›PMID 39443153›Full record

ArticleGenome research2024

Unraveling the architecture of major histocompatibility complex class II haplotypes in rhesus macaques.

Nanine de Groot, Marit van der Wiel, Ngoc Giang Le, Natasja G de Groot, Jesse Bruijnesteijn, Ronald E Bontrop

Abstract read
In one paragraph

Article in Genome research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Nanine de GrootDepartment of Comparative Genetics and Refinement, BPRC, 2288 GJ Rijswijk, the Netherlands.
Marit van der WielDepartment of Comparative Genetics and Refinement, BPRC, 2288 GJ Rijswijk, the Netherlands.
Ngoc Giang LeDepartment of Comparative Genetics and Refinement, BPRC, 2288 GJ Rijswijk, the Netherlands.
Natasja G de GrootDepartment of Comparative Genetics and Refinement, BPRC, 2288 GJ Rijswijk, the Netherlands.ORCID 0000-0001-6699-9345
Jesse Bruijnesteijn *Department of Comparative Genetics and Refinement, BPRC, 2288 GJ Rijswijk, the Netherlands; bruijnesteijn@bprc.nl.ORCID 0000-0002-7480-5376
Ronald E Bontrop *Department of Comparative Genetics and Refinement, BPRC, 2288 GJ Rijswijk, the Netherlands.ORCID 0000-0003-0874-6467

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The regions in the genome that encode components of the immune system are often featured by polymorphism, copy number variation, and segmental duplications. There is a need to thoroughly characterize these complex regions to gain insight into the impact of genomic diversity on health and disease. Here we resolve the organization of complete major histocompatibility complex (MHC) class II regions in rhesus macaques by using a long-read sequencing strategy (Oxford Nanopore Technologies) in concert with adaptive sampling. In particular, the expansion and contraction of the primate

Indexed as

HaplotypesMacaca mulattaAnimalsEvolution, MolecularHistocompatibility Antigens Class IIPseudogenesHistocompatibility Antigens Class II

Identifiers

PMID39443153
PMCPMC11610599

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.