Evidence map›Paper›PMID 39443151›Full record

ArticleAJNR. American journal of neuroradiology2025

Repeatability and Reproducibility of Pseudocontinuous Arterial Spin-Labeling-Measured Brain Perfusion in Healthy Volunteers and Patients with Glioblastoma.

Limin Zhou, Durga Udayakumar, Yiming Wang, Marco C Pinho, Benjamin C Wagner, Michael Youssef, Joseph A Maldjian, Ananth J Madhuranthakam

Registry-linked trialAbstract readClinical Study
PubMed Full text at PMC Publisher
In one paragraph

Article in AJNR. American journal of neuroradiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03922984 (A Prospective Study to Evaluate Quantitative Non-Contrast Perfusion Using Arterial Spin Labeled Magnetic Resonance), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03922984 nacompletednot on this map

A Prospective Study to Evaluate Quantitative Non-Contrast Perfusion Using Arterial Spin Labeled Magnetic Resonance (MR) Imaging for Assessment of Therapy Response in Glioblastoma

TypeinterventionalSponsorUniversity of Texas Southwestern Medical CenterRan2019 to 2024Enrolled43ConditionsGlioblastomaArmsMRI with Arterial Spin Labeling (ASL)
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Limin ZhouFrom the Department of Radiology (L.Z., D.U., YW., M.C.P., B.C.W. J.A.M. A.J.M.), Utah Southwestern Medical Center, Dallas, Texas.
Durga UdayakumarFrom the Department of Radiology (L.Z., D.U., YW., M.C.P., B.C.W. J.A.M. A.J.M.), Utah Southwestern Medical Center, Dallas, Texas.ORCID 0000-0002-8867-2869
Yiming WangFrom the Department of Radiology (L.Z., D.U., YW., M.C.P., B.C.W. J.A.M. A.J.M.), Utah Southwestern Medical Center, Dallas, Texas.
Marco C PinhoFrom the Department of Radiology (L.Z., D.U., YW., M.C.P., B.C.W. J.A.M. A.J.M.), Utah Southwestern Medical Center, Dallas, Texas.ORCID 0000-0002-4645-1638
Benjamin C WagnerFrom the Department of Radiology (L.Z., D.U., YW., M.C.P., B.C.W. J.A.M. A.J.M.), Utah Southwestern Medical Center, Dallas, Texas.
Michael YoussefDepartments of Neurology (M.Y.), UT Southwestern Medical Center, Dallas, Texas.
Joseph A MaldjianFrom the Department of Radiology (L.Z., D.U., YW., M.C.P., B.C.W. J.A.M. A.J.M.), Utah Southwestern Medical Center, Dallas, Texas.ORCID 0000-0002-6384-1072
Ananth J MadhuranthakamFrom the Department of Radiology (L.Z., D.U., YW., M.C.P., B.C.W. J.A.M. A.J.M.), Utah Southwestern Medical Center, Dallas, Texas ananth@mayo.edu.ORCID 0000-0002-5524-7962

Funding

Quantitative Non-Contrast Perfusion using Arterial Spin Labeling for Assessment of Cancer Therapy ResponseU01CA207091 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI MADHURANTHAKAM, ANANTH J, MALDJIAN, JOSEPH A · 2017 to 2022
$3.1M
Virtual Biopsy with Tissue-level Accuracy in GliomaR01CA260705 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI MALDJIAN, JOSEPH A · 2021 to 2025
$3.1M
NCI NIH HHS R01 CA260705NCI NIH HHS U01 CA207091
6 · The paper itself

Abstract

background and purposeArterial spin-labeling (ASL) MRI has gained recognition as a quantitative perfusion imaging method for managing patients with brain tumors. Limited studies have so far investigated the reproducibility of ASL-derived perfusion in these patients. This study aimed to evaluate intrasession repeatability and intersession reproducibility of perfusion measurements using 3D pseudocontinuous ASL (pCASL) with TSE Cartesian acquisition with spiral profile reordering (TSE-CASPR) in healthy volunteers (HV) and patients with glioblastoma (GBM) at 3T and to compare them against 3D pCASL with gradient and spin echo (GRASE). MATERIALS AND

methodsThis prospective study (NCT03922984) was approved by the institutional review board, and written informed consent was obtained from all subjects. HV underwent repeat pCASL evaluations 2-4 weeks apart between November 2021 and October 2022. Patients with GBM were recruited for longitudinal MRI from September 2019 to February 2023. Intrasession repeatability (HV and GBM) and intersession reproducibility (HV only) of pCASL were assessed using linear regression, Bland-Altman analyses, the intraclass correlation coefficient (ICC) with 95% CI, and within-subject coefficients of variation (wsCV).

resultsTwenty HV (9 men; mean age, 25.1 [SD, 1.7] years; range, 23-30 years) and 21 patients with GBM (15 men; mean age, 59.8 [SD, 14.3] years; range, 28-81 years) were enrolled. In imaging sessions, 3D pCASL-measured perfusion with TSE-CASPR and GRASE, respectively, achieved high

conclusionsOur study demonstrated excellent intrasession repeatability of 3D pCASL-measured cerebral perfusion in HV and patients with GBM and good-to-excellent intersession reproducibility in HV. 3D pCASL with GRASE performed slightly better than 3D pCASL with TSE-CASPR in HV; however, in patients with GBM, 3D pCASL with TSE-CASPR showed better performance in tumor regions with a nearly 2-fold higher SNR. ASL-measured perfusion could serve as a noncontrast quantitative imaging biomarker to facilitate the management of patients with GBM.

Indexed as

Brain NeoplasmsCerebrovascular CirculationGlioblastomaMagnetic Resonance AngiographyMagnetic Resonance ImagingAdultAgedAged, 80 and overFemaleHealthy VolunteersHumansMaleMiddle AgedProspective StudiesReproducibility of ResultsSpin LabelsSpin Labels

Identifiers

PMID39443151
PMCPMC12091990

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.