Evidence map›Paper›PMID 39442771›Full record

ArticleAnnals of epidemiology2024

Association between iron deficiency anemia and severe maternal morbidity: A retrospective cohort study.

Samuel H Nyarko, Lucy T Greenberg, George R Saade, Ciaran S Phibbs, Jeffrey S Buzas, Scott A Lorch, Jeannette Rogowski, Molly Passarella, Nansi S Boghossian

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PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of epidemiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Samuel H NyarkoDepartment of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, SC, United States.
Lucy T GreenbergVermont Oxford Network, Burlington, VT, United States.
George R SaadeDepartment of Obstetrics & Gynecology, Eastern Virginia Medical School, Norfolk, VA, United States.
Ciaran S PhibbsHealth Economics Resource Center and Center for Implementation to Innovation, Veterans Affairs Palo Alto Health Care System, Menlo Park, CA, United States; Departments of Pediatrics (Division of Neonatology) and Health Policy (by courtesy), Stanford University School of Medicine, Stanford, CA, United States.
Jeffrey S BuzasDepartment of Mathematics and Statistics, University of Vermont, Burlington, VT, United States.
Scott A LorchDepartment of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, PA, United States; Leonard Davis Institute of Health Economics, Wharton School, University of Pennsylvania, Philadelphia, PA, United States.
Jeannette RogowskiDepartment of Health Policy and Administration, The Pennsylvania State University, State College, PA, United States.
Molly PassarellaDepartment of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, PA, United States.
Nansi S BoghossianDepartment of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, SC, United States. Electronic address: nboghoss@mailbox.sc.edu.

Funding

Hospital quality, Medicaid expansion, and racial/ethnic disparitiesin maternal mortality and morbidityR01MD016012 · NIMHD · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI BOGHOSSIAN, NANSI · 2020 to 2024
$3.2M
Obstetric delivery volume, regionalization, and maternal and infant outcomesR01HD099197 · NICHD · STANFORD UNIVERSITY · PI PHIBBS, CIARAN S. · 2020 to 2023
$2.7M
Effect of Changing NICU Patient Volumes and Levels of Care on Neonatal OutcomesR01HD084819 · NICHD · STANFORD UNIVERSITY · PI LORCH, SCOTT A, PHIBBS, CIARAN S. · 2016 to 2018
$1.1M
NICHD NIH HHS R01 HD084819NICHD NIH HHS R01 HD099197NIMHD NIH HHS R01 MD016012
6 · The paper itself

Abstract

purposeWe examined the association between iron deficiency anemia (IDA) and severe maternal morbidity (SMM) during delivery and up to 1-year postpartum.

methodsIn a retrospective cohort study across 3 states, we computed adjusted relative risks (aRR) for SMM comparing individuals with IDA versus those without, using modified Poisson regression models.

resultsAmong 2459,106 individuals, 10.3 % (n = 252,240) had IDA. Individuals with IDA experienced higher rates of blood transfusion and non-transfusion SMM (329 and 122 per 10,000 deliveries, respectively) than those without IDA (33 and 46 per 10,000 deliveries, respectively). The risk of blood transfusion (aRR: 8.2; 95 % CI 7.9-8.5) and non-transfusion SMM (aRR: 1.9; 95 % CI: 1.8-2.0) were higher among individuals with IDA. The attributable risk per 10,000 deliveries due to IDA for blood transfusion and non-transfusion SMM during delivery were 29.5 (95 % CI: 28.9-30.0) and 5.7 (95 % CI: 5.3-6.2), respectively. Within 1-year postpartum, the relative risk of non-transfusion SMM (aRR:1.3; 95 % CI: 1.2-1.3) was 30 % higher among individuals with IDA.

conclusionIDA is associated with increased SMM risk. Addressing IDA in pregnant individuals may reduce SMM rates.

Indexed as

Anemia, Iron-DeficiencyBlood TransfusionAdultFemaleHumansMorbidityPostpartum PeriodPregnancyPregnancy Complications, HematologicRetrospective StudiesRisk FactorsUnited StatesYoung AdultAnemiaBlood transfusionDelivery hospitalizationMaternal morbidityPostpartum

Identifiers

PMID39442771
PMCPMC11625610

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.