Evidence map›Paper›PMID 39442646›Full record

ArticleBrain research2024

Variations of neuronal properties in the region of locus coeruleus of mice.

Lucas Silva Tortorelli, Machhindra Garad, Marine Megemont, Sachiko Haga-Yamanaka, Anubhuti Goel, Hongdian Yang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Lucas Silva TortorelliDepartment of Molecular, Cell and Systems Biology, University of California, Riverside, CA 92521, USA.
Machhindra GaradDepartment of Molecular, Cell and Systems Biology, University of California, Riverside, CA 92521, USA.
Marine MegemontDepartment of Molecular, Cell and Systems Biology, University of California, Riverside, CA 92521, USA.
Sachiko Haga-YamanakaDepartment of Molecular, Cell and Systems Biology, University of California, Riverside, CA 92521, USA; Neuroscience Graduate Program, University of California, Riverside, CA 92521, USA.
Anubhuti GoelDepartment of Psychology, University of California, Riverside, CA 92521, USA; Neuroscience Graduate Program, University of California, Riverside, CA 92521, USA.
Hongdian YangDepartment of Molecular, Cell and Systems Biology, University of California, Riverside, CA 92521, USA; Neuroscience Graduate Program, University of California, Riverside, CA 92521, USA. Electronic address: hongdian@ucr.edu.

Funding

Top-Down Mechanisms and Modulation of Flexible Tactile DiscriminationR01NS112200 · NINDS · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI Hongdian Yang, Edward W Zagha · 2019 to 2026
$2.8M
Locus Coeruleus-Norepinephrine Modulation of Sensory Response and Tactile PerceptionR01NS107355 · NINDS · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI YANG, HONGDIAN · 2019 to 2023
$1.7M
NINDS NIH HHS R01 NS107355NINDS NIH HHS R01 NS112200
6 · The paper itself

Abstract

Neurons in the locus coeruleus (LC) have been traditionally viewed as a homogenous population. Recent studies begin to reveal their heterogeneity at multiple levels, ranging from molecular compositions to projection targets. To further uncover variations of neuronal properties in the LC, we took a genetic-based tagging approach to identify these neurons. Our data revealed diverse spike waveforms among neurons in the LC region, including a considerable fraction of narrow-spiking units. While all wide-spiking units possessed the regular waveform polarity (negative-positive deflection), the narrow units can be further divided based on opposing waveform polarities. Under anesthesia, wide units emitted action potential at a higher rate than the narrow units. Under wakefulness, only one subtype of narrow units exhibited fast-spiking phenotype. These neurons also had long latencies to optogenetic stimulation. In-situ hybridization further supported the existence of a small population of putative GABAergic neurons in the LC core. Together, our data reveal characteristic differences among neurons in the LC region, and suggest that a fraction of electrophysiologically-identified narrow-spiking neurons can be fast-spiking interneurons, and their fast-spiking feature is masked by anesthesia.

Indexed as

Action PotentialsLocus CoeruleusNeuronsAnimalsGABAergic NeuronsInterneuronsMaleMiceMice, Inbred C57BLMice, TransgenicOptogeneticsWakefulnessFast spikingGABALocus coeruleusNarrow spikingSpike waveform

Identifiers

PMID39442646
PMCPMC12094211

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.