ArticleThe Journal of clinical investigation1986
Differential binding of immunoglobulin A and immunoglobulin G1 immune complexes to primate erythrocytes in vivo. Immunoglobulin A immune complexes bind less well to erythrocytes and are preferentially deposited in glomeruli.
Article in The Journal of clinical investigation, 1986. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 91 citations in OpenAlex.
- Antibody-mediated phagocytosis in cancer immunotherapy.Immunological reviews · 2023Review
- Acquired decrease of the C3b/C4b receptor (CR1, CD35) and increased C4d deposits on erythrocytes from ICU COVID-19 patients.Immunobiology · 2021Article
- Consumption of erythrocyte CR1 (CD35) is associated with protection against systemic lupus erythematosus renal flare.Clinical and experimental immunology · 2006Article
- A transgenic mouse model for studying the clearance of blood-borne pathogens via human complement receptor 1 (CR1).Clinical and experimental immunology · 2005Article
- A CR1 polymorphism associated with constitutive erythrocyte CR1 levels affects binding to C4b but not C3b.Immunology · 2003Article
- Of mice and men: the relevance of the mouse to the study of human SLE.Immunologic research · 2001Review
- In vivo clearance by the mononuclear phagocyte system in humans: an overview of methods and their interpretation.Clinical and experimental immunology · 1992Review
- Immune adherence and clearance of hepatitis B surface Ag/Ab complexes is abnormal in patients with systemic lupus erythematosus (SLE).Clinical and experimental immunology · 1991Article
- Immunoglobulin isotype composition of circulating and intra-articular immune complexes in patients with inflammatory joint disease.Rheumatology international · 1991Article
- Complement-mediated inhibition of immune precipitation in rheumatoid vasculitis.Rheumatology international · 1990Article
- Immune adherence of nascent hepatitis B surface antigen-antibody complexes in vivo in humans.Clinical and experimental immunology · 1989Article
- In vivo handling of soluble complement fixing Ab/dsDNA immune complexes in chimpanzees.The Journal of clinical investigation · 1989Article
- Elimination of soluble 123I-labelled aggregates of human immunoglobulin G in humans; the effect of splenectomy.Clinical and experimental immunology · 1989Article
- The role of hypocomplementaemia and low erythrocyte complement receptor type 1 numbers in determining abnormal immune complex clearance in humans.Clinical and experimental immunology · 1989Article
- Plasma factors influencing PGI2-like activity in patients with IgA nephropathy and Henoch-Schönlein purpura.Pediatric nephrology (Berlin, Germany) · 1989Article
- The rate of loss of CR1 from ageing erythrocytes in vivo in normal subjects and SLE patients: no correlation with structural or numerical polymorphisms.Clinical and experimental immunology · 1988Article
- Clearance of cryoglobulins in man.Springer seminars in immunopathology · 1988Review
- Role of fibronectin on the clearance and tissue uptake of antigen and immune complexes in rats.The Journal of clinical investigation · 1987Article
- Family study of the major histocompatibility complex in HLA DR3 negative patients with systemic lupus erythematosus.Clinical and experimental immunology · 1987Article
- A lysine-binding protein in SLE sera inhibits the binding of immune complexes to normal erythrocyte CR1 (complement receptor type 1).Clinical and experimental immunology · 1987Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Primate erythrocytes appear to play a role in the clearance of potentially pathogenic immune complexes (IC) from the circulation. This study was undertaken to compare the clearance from the circulation and tissue uptake of two monoclonal IC probes: one of which, IgG1-IC, was bound well by erythrocytes, the other of which, IgA-IC, was bound relatively poorly by erythrocytes. The IC probes were labeled with different iodine isotopes and infused either concomitantly or sequentially into the arterial circulation. The results indicate that, compared with IgG1-IC, IgA-IC bind less well to primate erythrocytes, are cleared from the circulation more quickly despite their smaller size, and show increased uptake in kidney and lung but decreased uptake in liver and spleen. Evidence is presented which suggests that this pattern of clearance from the circulation and systemic uptake of IgA-IC is the result of decreased binding of IgA-IC to circulating erythrocytes. These findings support the hypothesis that the primate erythrocyte-IC clearing mechanism may be critically important for the safe removal of IC from the circulation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.