ArticleNeurology2024
Association of Self-Reported Sleep Characteristics With Neuroimaging Markers of Brain Aging Years Later in Middle-Aged Adults.
Article in Neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Sleep architecture and self-reported sleep quality are associated with Alzheimer's disease biomarkers in older adults without dementia.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Trial
- Harnessing Brain Age-Specific Effects on the Associations Between Sleep Quality, Glymphatic Function, and Cognition in Normal Ageing Adults: Insights for Gerotherapeutics.Neurology and therapy · 2026Article
- Poor sleep is robustly correlated with accelerated aging but the evidence for causation is mixed.medRxiv : the preprint server for health sciences · 2026Article
- Association of sleep duration with Alzheimer's disease and cognition.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Midlife sleep characteristics and Alzheimer's disease biomarkers 20 years later.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Association between sleep duration and diabetic kidney disease: a cross-sectional study based on the National health and nutrition examination survey database (2005-2020).Diabetology & metabolic syndrome · 2026Article
- Modulation of the immunological and neuroinflammatory microenvironment in older people with multiple sclerosis.Frontiers in immunology · 2026Review
- Brain Age Acceleration on MRI Due to Poor Sleep: Associations, Mechanisms, and Clinical Implications.Brain sciences · 2025Review
- Poor sleep health is associated with older brain age: the role of systemic inflammation.EBioMedicine · 2025Article
- Findings and Methodological Shortcomings of Investigations Concerning the Relationship Between Sleep Duration and Blood Pressure: A Comprehensive Narrative Review.Journal of cardiovascular development and disease · 2025Review
- Do single people age faster? The answer may lie in sleep.Frontiers in aging · 2025Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
objectivesTo determine the association between early midlife sleep and advanced brain aging patterns in late midlife.
methodsUsing the CARDIA study, we analyzed sleep data at baseline and 5 years later, focusing on short sleep duration, bad sleep quality (SQ), difficulty initiating and maintaining sleep (DIS and DMS), early morning awakening (EMA), and daytime sleepiness. These were categorized into 0-1, 2-3, and >3 poor sleep characteristics (PSC). Brain MRIs obtained 15 years later were used to determine brain age through a machine learning approach based on age-related atrophy.
resultsThis cohort study included 589 participants (mean age 40.4 ± 3.4 years, 53% women). At baseline, around 70% reported 0-1 PSC, 22% reported 2%-3%, and 8% reported >3 PSC. In multivariable linear regression analyses, participants with 2-3 or >3 PSC had 1.6-year (β = 1.61, 95% CI 0.28-2.93) and 2.6-year (β = 2.64, 95% CI 0.59-4.69) older brain age, respectively, compared with those with 0-1 PSC. Of the individual characteristics, bad SQ, DIS, DMS, and EMA were associated with greater brain age, especially when persistent over the 5-year follow-up. DISCUSSION: Poor sleep was associated with advanced brain age in midlife, highlighting the importance of investigating early sleep interventions for preserving brain health.
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