Evidence map›Paper›PMID 39441986›Full record

ArticleJournal of medicinal chemistry2024

Targeting

Skye B Brettell, Omar Janha, Abbey Begen, Gillian Cann, Saumya Sharma, Niniola Olaniyan, Tamas Yelland, Alison J Hole, Benazir Alam, Emily Mayville and 7 more

Abstract read
In one paragraph

Article in Journal of medicinal chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Shaping Antimalarials: A Geometry-First Approach toJournal of medicinal chemistry · 2026
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Skye B BrettellSchool of Chemistry, The Advanced Research Centre, University of Glasgow, 11 Chapel Lane, Glasgow G11 6EW, U.K.ORCID 0009-0003-4026-916X
Omar JanhaCentre for Translational Pharmacology, The Advanced Research Centre, University of Glasgow, 11 Chapel Lane, Glasgow G11 6EW, U.K.
Abbey BegenKelticPharma Therapeutics, The Advanced Research Centre, University of Glasgow, 11 Chapel Lane, Glasgow G11 6EW, U.K.
Gillian CannKelticPharma Therapeutics, The Advanced Research Centre, University of Glasgow, 11 Chapel Lane, Glasgow G11 6EW, U.K.
Saumya SharmaKelticPharma Therapeutics, The Advanced Research Centre, University of Glasgow, 11 Chapel Lane, Glasgow G11 6EW, U.K.
Niniola OlaniyanCentre for Translational Pharmacology, The Advanced Research Centre, University of Glasgow, 11 Chapel Lane, Glasgow G11 6EW, U.K.
Tamas YellandEvotec (U.K.) Ltd, 95 Park Drive, Milton Park, Abingdon, Oxfordshire OX14 4RY, U.K.
Alison J HoleEvotec (U.K.) Ltd, 95 Park Drive, Milton Park, Abingdon, Oxfordshire OX14 4RY, U.K.
Benazir AlamEvotec (U.K.) Ltd, 95 Park Drive, Milton Park, Abingdon, Oxfordshire OX14 4RY, U.K.
Emily MayvilleDepartment of Microbiology& Immunology and Center for Malaria Therapeutics and Antimicrobial Resistance, Division of Infectious Diseases, Department of Medicine, Columbia University Medical Centre, New York, New York 10032, United States.
Ross GillespieSchool of Chemistry, The Advanced Research Centre, University of Glasgow, 11 Chapel Lane, Glasgow G11 6EW, U.K.
Michael CapperSchool of Chemistry, The Advanced Research Centre, University of Glasgow, 11 Chapel Lane, Glasgow G11 6EW, U.K.ORCID 0000-0003-0102-6993
David A FidockDepartment of Microbiology& Immunology and Center for Malaria Therapeutics and Antimicrobial Resistance, Division of Infectious Diseases, Department of Medicine, Columbia University Medical Centre, New York, New York 10032, United States.
Graeme MilliganCentre for Translational Pharmacology, The Advanced Research Centre, University of Glasgow, 11 Chapel Lane, Glasgow G11 6EW, U.K.ORCID 0000-0002-6946-3519
David J ClarkeEaSTCHEM School of Chemistry, University of Edinburgh, Joseph Black Building, David, Brewster Road, Edinburgh EH9 3FJ, U.K.ORCID 0000-0002-3741-2952
Andrew B TobinCentre for Translational Pharmacology, The Advanced Research Centre, University of Glasgow, 11 Chapel Lane, Glasgow G11 6EW, U.K.ORCID 0000-0002-1807-3123
Andrew G JamiesonSchool of Chemistry, The Advanced Research Centre, University of Glasgow, 11 Chapel Lane, Glasgow G11 6EW, U.K.ORCID 0000-0003-1726-7353

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Malaria still causes over 600,000 deaths annually, with rising resistance to frontline drugs by

Indexed as

AntimalarialsPlasmodium falciparumProtein Kinase InhibitorsCrystallography, X-RayHep G2 CellsHumansMalaria, FalciparumModels, MolecularProtein Serine-Threonine KinasesProtozoan ProteinsStructure-Activity RelationshipAntimalarialsProtein Kinase InhibitorsProtein Serine-Threonine KinasesProtozoan Proteins

Identifiers

PMID39441986
PMCPMC11571108

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.