ArticleScience advances2024
An autonomous implantable device for the prevention of death from opioid overdose.
Article in Science advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed.
- A Wireless Wearable Platform for Intravenous Drug Self-Administration in Freely Behaving Rats.bioRxiv : the preprint server for biology · 2026Article
- Multiwavelength Implantable Oximeter for Wireless Monitoring of Tissue Oxygenation in the Presence of Blood Volume Changes.Advanced healthcare materials · 2026Article
- A wearable acoustofluidic patch for rapid reversal of opioid overdose.Nature communications · 2026Article
- Coordinated control of miniature magnetic pumps for liquid sampling and delivery in a knee implant.Device · 2026Article
- A Fentanyl-Responsive Microneedle Patch for Harm Reduction.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Smart contact lens-trained digital twin for device-free personalized uric acid prediction.Science advances · 2026Article
- Tissue-bioelectronics interfaces.Chemical Society reviews · 2026Review
- Fully Wireless and Flexible Valves for Multiplexed and Prolonged Intravesical Liquid Release.Advanced healthcare materials · 2026Article
- Dynamic and living devices for overcoming fibrosis of implanted biomaterials.Bioengineering & translational medicine · 2026Review
- Perceptions and Preferences Regarding Opioid Sensor Devices: A Theory-Driven Cross-Sectional Survey of Community Responders and Healthcare Providers.Healthcare (Basel, Switzerland) · 2026Article
- Materials and System Design for Self-Decision Bioelectronic Systems.Advanced materials (Deerfield Beach, Fla.) · 2026Review
- Emergency delivery of particulate drugs by active ejection using in vivo wireless devices.Nature biomedical engineering · 2026Article
- Emerging Implantable Sensor Technologies at the Intersection of Engineering and Brain Science.Biosensors · 2025Review
- Smart closed-loop drug delivery systems.Nature reviews bioengineering · 2025Article
- Autonomous devices for drug delivery.Nature biomedical engineering · 2025Article
- Implantable bioelectronics and wearable sensors for kidney health and disease.Nature reviews. Nephrology · 2025Review
- Intranasal overdose reversal formulations: a rapid review of available agents.Pain management · 2025Review
Corrections and comments
- Update of
Authors and funding
26 authors.
Funding
Abstract
Opioid overdose accounts for nearly 75,000 deaths per year in the United States, now a leading cause of mortality among young people aged 18 to 45 years. At overdose levels, opioid-induced respiratory depression becomes fatal without the administration of naloxone within minutes. Currently, overdose survival relies on bystander intervention, requiring a nearby person to find the overdosed individual and have immediate access to naloxone to administer. To circumvent the bystander requirement, we developed the Naloximeter: a class of life-saving implantable devices that autonomously detect and treat overdose while simultaneously contacting first responders. We present three Naloximeter platforms, for fundamental research and clinical translation, all equipped with optical sensors, drug delivery mechanisms, and a supporting ecosystem of technology to counteract opioid-induced respiratory depression. In small and large animal studies, the Naloximeter rescues from otherwise fatal opioid overdose within minutes. This work introduces life-changing, clinically translatable technologies that can broadly benefit a susceptible population recovering from opioid use disorder.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.