Evidence map›Paper›PMID 39441922›Full record

ArticleScience advances2024

Creation of true interspecies hybrids: Rescue of hybrid class with hybrid cytoplasm affecting growth and metabolism.

Leyla Sati, Luis Varela, Tamas L Horvath, James McGrath

Abstract read
In one paragraph

Article in Science advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Leyla SatiDepartment of Histology and Embryology, Akdeniz University School of Medicine, 07070 Antalya, Turkey.ORCID 0000-0002-1801-2021
Luis VarelaDepartment of Comparative Medicine, Yale University School of Medicine, New Haven, CT 06520, USA.ORCID 0000-0001-7794-7241
Tamas L HorvathDepartment of Comparative Medicine, Yale University School of Medicine, New Haven, CT 06520, USA.ORCID 0000-0002-7522-4602
James McGrathDepartments of Comparative Medicine and Genetics, Yale University School of Medicine, New Haven, CT 06520, USA.

Funding

The role of AgRP/Auga-ALK pathway in FGF21's brain action on agingP01AG051459 · NIA · YALE UNIVERSITY · PI PHILIPP E SCHERER · 2016 to 2026
$25.7M
Hypothalamus-driven anti-aging processes impact murine models of Alzheimer's DiseaseR01AG067329 · NIA · YALE UNIVERSITY · PI HORVATH, TAMAS L · 2020 to 2024
$3.2M
Hypothalamic AgRP Neurons Are Determinants of Healthy Lifespan and Higher Brain DP1DK098058 · NIDDK · YALE UNIVERSITY · PI HORVATH, TAMAS L · 2012 to 2014
$2.4M
Augmenting AXL and MERTK function to restrain cognitive decline and improve health span in mouse models of Alzheimer's DiseaseRF1AG082190 · NIA · YALE UNIVERSITY · PI GHOSH, SOURAV, GRUTZENDLER, JAIME · 2023 to 2023
$2.4M
The role of mitochondrial dynamics in diet-influenced regulation of food intake and adiposityR01DK126447 · NIDDK · YALE UNIVERSITY · PI HORVATH, TAMAS L, RODEHEFFER, MATTHEW S · 2021 to 2024
$2.3M
Investigations of Mouse Interspecies HybridsR21HD072532 · NICHD · YALE UNIVERSITY · PI MCGRATH, JAMES M · 2012 to 2013
$447k
NIA NIH HHS P01 AG051459NIA NIH HHS R01 AG067329NIA NIH HHS RF1 AG082190NICHD NIH HHS R21 HD072532NIDDK NIH HHS DP1 DK098058NIDDK NIH HHS R01 DK126447
6 · The paper itself

Abstract

Interspecies hybrids have nuclear contributions from two species but oocyte cytoplasm from only one. Species discordance may lead to altered nuclear reprogramming of the foreign paternal genome. We reasoned that initial reprogramming in same species cytoplasm plus creation of hybrids with zygote cytoplasm from both species, which we describe here, might enhance nuclear reprogramming and promote hybrid development. We report in

Indexed as

CytoplasmHybridization, GeneticAnimalsCell NucleusChimeraFemaleHybrid CellsMaleMiceOocytesPhenotype

Identifiers

PMID39441922
PMCPMC11498210

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.