Evidence map›Paper›PMID 39441646›Full record

ArticleCancer reports (Hoboken, N.J.)2024

Plasma Profiling of Acute Myeloid Leukemia With Fever- and Infection-Related Complications During Chemotherapy-Induced Neutropenia.

Iris C Kreft, Annemarie van de Geer, Eva R Smit, Carmen van der Zwaan, Floris P J van Alphen, Alexander B Meijer, Erfan Nur, Arie J Hoogendijk, Taco W Kuijpers, Maartje van den Biggelaar

Abstract read
In one paragraph

Article in Cancer reports (Hoboken, N.J.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Plasma Proteomic Profile of Chemotherapy-Induced Severe Neutropenia: A Pilot Discovery Phase Study.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Iris C KreftDepartment of Molecular Hematology, Sanquin Research, Amsterdam, The Netherlands.ORCID 0000-0002-3595-992X
Annemarie van de GeerDepartment of Blood Cell Research, Division Research and Landsteiner Laboratory of Amsterdam UMC, Sanquin Blood Supply, Amsterdam, The Netherlands.
Eva R SmitDepartment of Molecular Hematology, Sanquin Research, Amsterdam, The Netherlands.
Carmen van der ZwaanDepartment of Molecular Hematology, Sanquin Research, Amsterdam, The Netherlands.
Floris P J van AlphenDepartment of Molecular Hematology, Sanquin Research, Amsterdam, The Netherlands.
Alexander B MeijerDepartment of Molecular Hematology, Sanquin Research, Amsterdam, The Netherlands.
Erfan NurDepartment of Hematology, Amsterdam UMC, location AMC, Amsterdam, The Netherlands.
Arie J HoogendijkDepartment of Molecular Hematology, Sanquin Research, Amsterdam, The Netherlands.
Taco W KuijpersDepartment of Blood Cell Research, Division Research and Landsteiner Laboratory of Amsterdam UMC, Sanquin Blood Supply, Amsterdam, The Netherlands.
Maartje van den BiggelaarDepartment of Molecular Hematology, Sanquin Research, Amsterdam, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAcute myeloid leukemia (AML) is a heterogenous and complex blood cancer requiring aggressive treatment. Early identification and prediction of the complications following treatment is vital for effective disease management.

aimsWe explored associations between plasma protein levels and fever- and infection-related complications in 26 AML patients during chemotherapy-induced neutropenia. MATERIAL AND

methodsLongitudinal plasma profiling was conducted using data-dependent mass spectrometry analysis.

resultsMass spectrometry-based plasma profiling data correlated well with laboratory parameters, including C-reactive protein, and revealed a broader inflammation protein network associated with fever- and infection-related complications. DISCUSSION AND

conclusionThese data indicate the potential of longitudinal plasma profiling in AML patients for identifying and predicting complications that may aid in improved disease monitoring and treatment.

Indexed as

FeverLeukemia, Myeloid, AcuteAdultAgedAntineoplastic Combined Chemotherapy ProtocolsChemotherapy-Induced Febrile NeutropeniaC-Reactive ProteinFemaleHumansInfectionsLongitudinal StudiesMaleMiddle AgedNeutropeniaYoung AdultC-Reactive Proteinacute myeloid leukemiamass spectrometryplasmaplasma profilingproteomics

Identifiers

PMID39441646
PMCPMC11498059

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.