Evidence map›Paper›PMID 39441630›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2024

Cryo-EM structure of the zinc-activated channel (ZAC) in the Cys-loop receptor superfamily.

Fei Jin, Yi-Yu Lin, Ru-Chun Wang, Tang-Xuan Xie, Yimeng Zhao, Cheng Shen, Danqi Sheng, Muneyoshi Ichikawa, Ye Yu, Jin Wang and 1 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Cryo-EM structure of the zinc-activated channel (ZAC) in the Cys-loop receptor superfamily.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Fei Jin *State Key Laboratory of Genetic Engineering, Shanghai Key Laboratory of Bioactive Small Molecules, Collaborative Innovation Center of Genetics and Development, Department of Physiology and Neurobiology, School of Life Sciences, Fudan University, Shanghai 200438, China.
Yi-Yu Lin *Department of Basic Medicine, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing 200098, China.
Ru-Chun WangDepartment of Basic Medicine, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing 200098, China.
Tang-Xuan XieDepartment of Basic Medicine, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing 200098, China.ORCID 0009-0006-0084-4782
Yimeng ZhaoState Key Laboratory of Genetic Engineering, Shanghai Key Laboratory of Bioactive Small Molecules, Collaborative Innovation Center of Genetics and Development, Department of Physiology and Neurobiology, School of Life Sciences, Fudan University, Shanghai 200438, China.ORCID 0000-0002-8913-3568
Cheng ShenState Key Laboratory of Genetic Engineering, Shanghai Key Laboratory of Bioactive Small Molecules, Collaborative Innovation Center of Genetics and Development, Department of Physiology and Neurobiology, School of Life Sciences, Fudan University, Shanghai 200438, China.
Danqi ShengState Key Laboratory of Genetic Engineering, Shanghai Key Laboratory of Bioactive Small Molecules, Collaborative Innovation Center of Genetics and Development, Department of Physiology and Neurobiology, School of Life Sciences, Fudan University, Shanghai 200438, China.
Muneyoshi IchikawaState Key Laboratory of Genetic Engineering, Department of Biochemistry and Biophysics, School of Life Sciences, Fudan University, Shanghai 200438, China.ORCID 0000-0002-5921-7699
Ye YuDepartment of Basic Medicine, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing 200098, China.
Jin WangDepartment of Chemistry, School of Science, China Pharmaceutical University, Nanjing 200098, China.ORCID 0000-0001-8337-0434
Motoyuki HattoriState Key Laboratory of Genetic Engineering, Shanghai Key Laboratory of Bioactive Small Molecules, Collaborative Innovation Center of Genetics and Development, Department of Physiology and Neurobiology, School of Life Sciences, Fudan University, Shanghai 200438, China.ORCID 0000-0002-5327-5337

Funding

| E-Institutes of Shanghai Municipal Education Commission ZDSYS14005MEXT | Japan Science and Technology Agency (JST) JPMJPR20E1MOST | National Natural Science Foundation of China (NSFC) 32000869MOST | National Natural Science Foundation of China (NSFC) 32250610205MOST | National Natural Science Foundation of China (NSFC) 32271244
6 · The paper itself

Abstract

Cys-loop receptors are a large superfamily of pentameric ligand-gated ion channels with various physiological roles, especially in neurotransmission in the central nervous system. Among them, zinc-activated channel (ZAC) is a Zn

Indexed as

Cryoelectron MicroscopyCysteine Loop Ligand-Gated Ion Channel ReceptorsZincHumansIon Channel GatingModels, MolecularMutationProtein ConformationCysteine Loop Ligand-Gated Ion Channel ReceptorsZinccryo-EMion channelspatch clamp

Identifiers

PMID39441630
PMCPMC11536092

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.