Evidence map›Paper›PMID 39441537›Full record

ArticleInternational journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics2025

Adenomyosis: A potential cause of surgical failure in treating dyspareunia in rectovaginal septum endometriosis.

Antonio Mercorio, Luigi Della Corte, Michela Dell'Aquila, Daniela Pacella, Giuseppe Bifulco, Pierluigi Giampaolino

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Article in International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

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6citing papers in PubMed
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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
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  4. Adenomyosis: A potential cause of surgical failure in treating dyspareunia in rectovaginal septum endometriosis.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2025
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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Antonio MercorioDepartment of Public Health, School of Medicine, University of Naples Federico II, Naples, Italy.
Luigi Della CorteDepartment of Neuroscience, Reproductive Sciences and Dentistry, School of Medicine, University of Naples Federico II, Naples, Italy.ORCID https://orcid.org/0000-0002-0584-2181
Michela Dell'AquilaDepartment of Public Health, School of Medicine, University of Naples Federico II, Naples, Italy.
Daniela PacellaDepartment of Public Health, School of Medicine, University of Naples Federico II, Naples, Italy.
Giuseppe BifulcoDepartment of Public Health, School of Medicine, University of Naples Federico II, Naples, Italy.
Pierluigi GiampaolinoDepartment of Public Health, School of Medicine, University of Naples Federico II, Naples, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveDyspareunia can severely impact the quality of life of patients with endometriosis. This symptom is often linked to a specific form of deep infiltrating endometriosis, such as rectovaginal septum endometriosis. Despite the radicality of surgery, persistence and recurrence of symptoms post-surgery are not uncommon. The aim of the present study was to determine whether adenomyosis contributes to the failure of surgical interventions for dyspareunia in these patients.

methodsA retrospective single-cohort study was conducted at the at tertiary care gynecologic center of the University Federico II of Naples, using medical records from January 2020 to July 2023. The study included patients who underwent surgery for dyspareunia associated with rectovaginal endometriosis and had a definitive histologic diagnosis. Pain and sexual quality of life were assessed using the visual analog scale (VAS) and the sexual quality of life-female (SQoL-F) questionnaire, both before and 6 months after surgery. Patients with isolated rectovaginal endometriosis were compared to those with concurrent adenomyosis.

resultsA total of 94 patients were included: thirty-five in group A (endometriosis with adenomyosis) and 59 in group B (isolated rectovaginal endometriosis). Histology confirmed deep infiltrating endometriosis (DIE) in all patients. Clinical characteristics such as age, BMI, abnormal uterine bleeding, and infertility, showed no significant differences between the groups. Multiparity was more common in group A (20%) compared to group B (5.1%) (P < 0.001). Pain VAS scores decreased significantly in both groups: from 7.11 to 5.40 in group A and from 7.34 to 3.31 in group B (both P < 0.001). Sexual quality of life (SQoL) scores improved significantly: from 42 to 57 in group A and from 41 to 66 in group B (both P < 0.001). Patients in group B showed a more significant improvement. Adjusted linear regression showed no significant association between parity and the severity of dyspareunia or sexual quality of life.

conclusionAdenomyosis appears to reduce the effectiveness of surgical treatment for dyspareunia in patients with rectovaginal septum endometriosis. Comprehensive preoperative screening for adenomyosis is recommended to improve surgical outcomes and provide appropriate counseling. Future research should further explore the impact of adenomyosis on dyspareunia and the potential benefits of adjunctive medical therapies.

Indexed as

AdenomyosisDyspareuniaEndometriosisRectal DiseasesVaginal DiseasesAdultFemaleHumansMiddle AgedQuality of LifeRetrospective StudiesTreatment Failureadenomyosisdeep dyspareuniadeep infiltrating endometriosisendometriosisrectovaginal septumsexual quality of life

Identifiers

PMID39441537
PMCPMC11823326

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.