ArticleAllergy2025
Increasing prevalence of galactose-α-1,3-galactose sensitization in the Danish general adult population.
Article in Allergy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Tick bite prevention and management: integrating patient perspectives to shape patient education.Asia Pacific allergy · 2026Article
- Alpha-gal sensitization and allergic blood transfusion reactions: a scoping review.Journal of translational medicine · 2026Article
- From vector to allergen: exploring the immunology of tick-triggered α-Gal syndrome.Frontiers in immunology · 2026Review
- Allergic reactions associated with tsetse fly bites.Annals of medicine · 2025Article
- Alpha-Gal Syndrome-A Series of Cases with Different Clinical Pictures.International journal of molecular sciences · 2025Article
- Living close to the forest is a risk factor for galactose-α-1,3-galactose sensitization.The journal of allergy and clinical immunology. Global · 2025Article
- Alpha-Gal Sensitization Dynamics in Individuals After Tick Bites With or Without Erythema Migrans.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2025Article
- Increasing prevalence of galactose-α-1,3-galactose sensitization in the Danish general adult population.Allergy · 2025Article
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Authors and funding
11 authors.
Funding
Abstract
backgroundAlpha-gal syndrome is a novel food allergy to the oligosaccharide galactose-α-1,3-galactose (alpha-gal) present in mammalian meat. Tick bites are considered an important route of sensitization to alpha-gal. Data on alpha-gal sensitization in the general population is scant. We utilized a unique data source of repeated population-based health examination studies to assess prevalence, time trends, risk factors, and characteristics of alpha-gal sensitization.
methodsAlpha-gal sensitization was assessed in >11.000 adults from four health examination studies of randomly invited residents in the Copenhagen region conducted in 1990-1991, 2011-2012, 2012-2015, and 2016-2017. Alpha-gal sensitization was defined as serum specific IgE (sIgE) to alpha-gal ≥0.1 kU
resultsThe prevalence of sIgE to alpha-gal ≥0.1 kUA/L was 1.3% in 1990-1991, 3.7% in 2012-2015 and 3.2% in 2016-2017. Of those sensitized to alpha-gal >97% reported to consume red meat at least once a week, even for sIgE to alpha-gal ≥3.5 kU
conclusionIn this general adult population, the prevalence of alpha-gal sensitization had doubled from 1990-1991 to 2016-2017. This could potentially be due to increased tick exposure and an increased atopic predisposition.
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