Evidence map›Paper›PMID 39441425›Full record

ArticleAnnals of intensive care2024

Inter-lung asymmetrical airway closure cause insufflation delay between lungs in acute hypoxemic respiratory failure.

Hadrien Rozé, Eline Bonnardel, Eloise Gallo, Clément Boisselier, Pierre Khan, Virginie Perrier, Benjamin Repusseau, Laurent Brochard

Abstract read
In one paragraph

Article in Annals of intensive care, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Hadrien RozéRéanimation Polyvalente, Centre Hospitalier Côte Basque, Bayonne, F-64100, France. hroze@ch-cotebasque.fr.ORCID https://orcid.org/0000-0002-8256-2773
Eline BonnardelCHU de Bordeaux, Service d'Anesthésie-Réanimation Thoraco-Abdominale, Pessac, F-33600, France.
Eloise GalloCHU de Bordeaux, Service d'Anesthésie-Réanimation Thoraco-Abdominale, Pessac, F-33600, France.
Clément BoisselierCHU de Bordeaux, Service d'Anesthésie-Réanimation Thoraco-Abdominale, Pessac, F-33600, France.
Pierre KhanCHU de Bordeaux, Service d'Anesthésie-Réanimation Thoraco-Abdominale, Pessac, F-33600, France.
Virginie PerrierCHU de Bordeaux, Service d'Anesthésie-Réanimation Thoraco-Abdominale, Pessac, F-33600, France.
Benjamin RepusseauCHU de Bordeaux, Service d'Anesthésie-Réanimation Thoraco-Abdominale, Pessac, F-33600, France.
Laurent BrochardKeenan Research Centre, Li Ka Shing Knowledge Institute, St Michael's Hospital, Toronto, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundElectrical Impedance Tomography (EIT) can quantify ventilation in the two lungs and be used to measure the airway opening pressure (AOP) of each lung. Asymmetrical AOPs can cause inter-lung insufflation delay.

objectivesTo assess the relation between AOP asymmetry and inter-lung insufflation delay at different PEEP levels.

methodsPatients with acute hypoxemic respiratory failure and airway closure were included. Low-flow pressure-volume curves and EIT signal were recorded during controlled ventilation and for some patients in pressure support ventilation.

results23 patients were studied, 22 patients had ARDS, 9 patients had asymmetrical airway closure with an AOP of 10 [6-13] cmH

conclusionIn asymmetrical airway closure, titrating PEEP can minimize inter-lung insufflation delay and can be monitored by EIT. Reducing the delay and reducing ventilation asymmetry is also feasible during pressure support ventilation when low flow inflation curves cannot be performed.

Indexed as

Airway opening pressureAsynchronyElectrical impedance tomographyLung injuryMechanical ventilationProtective ventilationRespiratory mechanics

Identifiers

PMID39441425
PMCPMC11499510

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.