Evidence map›Paper›PMID 39441378›Full record

ReviewVirchows Archiv : an international journal of pathology2024

Non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP): what do we need to know?

Andrés Coca-Pelaz, Juan P Rodrigo, Abbas Agaimy, Dana M Hartl, Göran Stenman, Vincent Vander Poorten, Antti A Mäkitie, Mark Zafereo, Karthik N Rao, Gregory W Randolph and 2 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Virchows Archiv : an international journal of pathology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. The actual and future role of molecular tests in thyroid pathology.Virchows Archiv : an international journal of pathology · 2026
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Andrés Coca-PelazDepartment of Otolaryngology, Hospital Universitario Central de Asturias, University of Oviedo, ISPA, IUOPA, CIBERONC, Av/ Roma s/n. 33011, Oviedo, Asturias, Spain. acocapelaz@yahoo.es.
Juan P RodrigoDepartment of Otolaryngology, Hospital Universitario Central de Asturias, University of Oviedo, ISPA, IUOPA, CIBERONC, Av/ Roma s/n. 33011, Oviedo, Asturias, Spain.
Abbas AgaimyInstitute of Pathology, Friedrich Alexander University Erlangen-Nürnberg, University Hospital, Erlangen, Germany.
Dana M HartlThyroid Surgery Unit, Department of Otorhinolaryngology-Head and Neck Surgery, Institute Gustave Roussy, Paris, France.
Göran StenmanDepartment of Pathology, Sahlgrenska Center for Cancer Research, University of Gothenburg, Gothenburg, Sweden.
Vincent Vander PoortenDepartment of Oncology, Section Head and Neck Oncology, KU Leuven, Leuven, Belgium.
Antti A MäkitieDepartment of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine, Research Program in Systems Oncology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Mark ZafereoDepartment of Head and Neck Surgery, MD Anderson Cancer Center, Houston, TX, USA.
Karthik N RaoDepartment of Head and Neck Surgical Oncology, Sri Shankara Cancer Hospital and Research Center, Bangalore, India.
Gregory W RandolphDivision of Thyroid and Parathyroid Endocrine Surgery, Department of Otolaryngology-Head and Neck Surgery, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA, USA.
Alessandra RinaldoENT Unit, Policlinico Città di Udine, Udine, Italy.
Alfio FerlitoCoordinator of the International Head and Neck Scientific Group, Padua, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) is a recently defined thyroid nodule category characterized by follicular architecture with papillary nuclear features but lacking classical papillary carcinoma features like papillae or psammoma bodies. The diagnosis of NIFTP is based on histological examination and excludes cases with high-risk mutations like BRAFV600E. NIFTP carries a low risk of recurrence and distant metastasis, prompting a more conservative surgical approach compared to classical papillary thyroid carcinoma. The management of NIFTP typically involves lobectomy with postoperative monitoring of thyroglobulin levels and performing neck ultrasounds. While the identification of NIFTP represents a significant advancement in thyroid cancer diagnosis, challenges remain in refining preoperative diagnostic tools and establishing optimal long-term follow-up strategies. The objective of this review is to provide a comprehensive overview of NIFTP, including its histopathological characteristics, molecular profile, clinical presentation, diagnostic criteria, management strategies, and future research directions.

Indexed as

Adenocarcinoma, FollicularThyroid NeoplasmsHumansThyroid Cancer, PapillaryFine-needle aspiration cytologyNon-invasive follicular thyroid neoplasm with papillary-like nuclear featuresPapillary thyroid carcinomaRisk of malignancyThyroid

Identifiers

PMID39441378

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.