Evidence map›Paper›PMID 39441230›Full record

Observational studyBiological trace element research2025

Iodine Excess Is Associated with Thyroid Dysfunction Among the Elderly.

Qi Jin, Zhangzhao Wang, Junjing Li, Hexi Zhang, Mengxin Liu, Chunxi Wang, Wenxing Guo, Wanqi Zhang

Registry-linked trialAbstract readMulticenter StudyObservational Study
PubMed Publisher
In one paragraph

Observational study in Biological trace element research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05716191 (Study on the Relationship Between Iodine Nutrition and Thyroid Diseases in the Elderly), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05716191 unknown statusnot on this map

Study on the Relationship Between Iodine Nutrition and Thyroid Diseases in the Elderly

TypeobservationalSponsorTianjin Medical UniversityRan2023 to 2025Enrolled1,000ConditionsNutrition, Healthy, ElderlyArmsNaturally different iodine levels exposure
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Qi Jin *Department of Nutrition and Food Hygiene, School of Public Health, Tianjin Medical University, #22 Qixiangtai Street, Heping District, Tianjin, 300070, China.
Zhangzhao Wang *Department of Nutrition and Food Hygiene, School of Public Health, Tianjin Medical University, #22 Qixiangtai Street, Heping District, Tianjin, 300070, China.
Junjing LiDepartment of Nutrition and Food Hygiene, School of Public Health, Tianjin Medical University, #22 Qixiangtai Street, Heping District, Tianjin, 300070, China.
Hexi ZhangDepartment of Nutrition and Food Hygiene, School of Public Health, Tianjin Medical University, #22 Qixiangtai Street, Heping District, Tianjin, 300070, China.
Mengxin LiuDepartment of Nutrition and Food Hygiene, School of Public Health, Tianjin Medical University, #22 Qixiangtai Street, Heping District, Tianjin, 300070, China.
Chunxi WangDepartment of Nutrition and Food Hygiene, School of Public Health, Tianjin Medical University, #22 Qixiangtai Street, Heping District, Tianjin, 300070, China.
Wenxing GuoDepartment of Nutrition and Food Hygiene, School of Public Health, Tianjin Medical University, #22 Qixiangtai Street, Heping District, Tianjin, 300070, China. guowenxing@tmu.edu.cn.ORCID http://orcid.org/0000-0002-5669-4836
Wanqi ZhangDepartment of Nutrition and Food Hygiene, School of Public Health, Tianjin Medical University, #22 Qixiangtai Street, Heping District, Tianjin, 300070, China.

Funding

National Natural Science Foundation of China 82204041
6 · The paper itself

Abstract

The relationship between high water iodine levels and thyroid dysfunction in the elderly remains poorly understood. This study aimed to elucidate how excessive iodine in drinking water affects iodine nutrition and thyroid function in the elderly population. This cross-sectional study was performed in the elderly in Yuncheng, Heze, Shandong. We identified a total of 385 patients with thyroid dysfunction and 385 propensity score-matched controls with euthyroid. Water, urinary, and blood samples were collected to detect the concentrations of iodine in water and urine, as well as thyroid hormones. The median (IQR) iodine concentrations in cooking water and drinking water for the total population were 294.99 (48.99, 478.14) µg/L and 172.87 (20.87, 462.13) µg/L, respectively. Among the elderly, median (IQR) urinary iodine concentration (UIC) was 394.20 (169.47, 764.41) µg/L, and 24-h urinary iodine concentration (24-h UIE) was 523.04 (277.84, 910.76) µg/day. Subjects with thyroid dysfunction reported higher intake of iodine from water (P < 0.001) and urinary iodine levels (P < 0.001) than controls. Logistic regression analysis showed thyroid dysfunction was associated with higher risks of elevated iodine concentrations in cooking water (OR 1.957, 95% CI 1.413-2.711), drinking water (OR 2.206, 95% CI 1.607-3.027), UIC (OR 3.612, 95% CI 2.494-5.230), and 24-h UIE (OR 2.568, 95% CI 1.784-3.698), indicating increased thyroid dysfunction risk among the elderly with high water iodine levels. Elevated iodine levels in water are associated with an increased risk of thyroid dysfunction among the elderly. Clinical trial registry number: Medical Ethics Committee of Tianjin Medical University; Trial registration number: NCT05716191, date of registration was December 08, 2023.

Indexed as

IodineThyroid DiseasesAgedAged, 80 and overChinaCross-Sectional StudiesDrinking WaterFemaleHumansMaleMiddle AgedThyroid GlandDrinking WaterIodineHigh water iodineIodineThe elderlyThyroid dysfunction

Identifiers

PMID39441230

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.