Evidence map›Paper›PMID 39441168›Full record

ArticleLa Tunisie medicale2024

Zohra Chadli, Kmar Kasraoui, Ibtissem Hannachi, Amel Chaabane, Rim Klii, Haifa Ben Romdhane, Naceur A Boughattas, Nadia Ben Fredj, Karim Aouam

Abstract readEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Article in La Tunisie medicale, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Zohra ChadliDepartment of Pharmacology, University Hospital of Monastir, Faculty of Medicine, University of Monastir, Tunisia.
Kmar KasraouiDepartment of Pharmacology, University Hospital of Monastir, Faculty of Medicine, University of Monastir, Tunisia.
Ibtissem HannachiDepartment of Pharmacology, University Hospital of Monastir, Faculty of Medicine, University of Monastir, Tunisia.
Amel ChaabaneDepartment of Pharmacology, University Hospital of Monastir, Faculty of Medicine, University of Monastir, Tunisia.
Rim KliiInternal Medicine Department, University Hospital of Monastir, Tunisia.
Haifa Ben RomdhaneDepartment of Pharmacology, University Hospital of Monastir, Faculty of Medicine, University of Monastir, Tunisia.
Naceur A BoughattasDepartment of Pharmacology, University Hospital of Monastir, Faculty of Medicine, University of Monastir, Tunisia.
Nadia Ben FredjDepartment of Pharmacology, University Hospital of Monastir, Faculty of Medicine, University of Monastir, Tunisia.
Karim AouamDepartment of Pharmacology, University Hospital of Monastir, Faculty of Medicine, University of Monastir, Tunisia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction-Aim: The iatrogenic risk in the elderly is a real public health problem due to its frequency and seriousness. Our study aimed to analyze the epidemiological, clinical and chronological aspects of adverse drug reactions occurring in elderly subjects and to identify the incriminated drugs.

methodsWe carried out a retrospective study of all the observations of adverse drug reactions in elderly subjects, notified to the Clinical Pharmacology department of Monastir over a period of 17 years (2004 - 2020). Drug skin tests were performed according to ENDA recommendations and imputability was analyzed using the French method of Bégaud et al. The drugs have been grouped according to the ATC classification.

resultsAmong 545 events occurring in elderly subjects, drug responsibility was retained in 209 patients. They were 106 men and 103 women (gender-ratio=1.03). The average age of the patients was 72.3±6 years. Drug hypersensitivity reactions accounted for 75% of all adverse effects. The majority of these reactions were type IV (delayed). The incriminated drugs were: anti-infectives (47%), drugs for the musculoskeletal system (20%), drugs for the cardiovascular system (17%) and drugs for the central nervous system (5%).

conclusionThrough this study, we noted a predominance of delayed drug hypersensitivity reactions as well as an increased involvement of anti-infectives and allopurinol in the occurrence of adverse effects in the elderly population.

Indexed as

Drug-Related Side Effects and Adverse ReactionsIatrogenic DiseaseAgedAged, 80 and overDrug HypersensitivityFemaleHumansMaleRetrospective StudiesRisk FactorsAdverse drug reactionsElderlygeriatricsPharmacoepidemiology

Identifiers

PMID39441168
PMCPMC11574366

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Registered trials

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