Evidence map›Paper›PMID 39440978›Full record

ArticlemBio2024

Metal availability shapes early life microbial ecology and community succession.

Joshua Soto Ocaña, Elliot S Friedman, Orlaith Keenan, Nile U Bayard, Eileen Ford, Ceylan Tanes, Matthew J Munneke, William N Beavers, Eric P Skaar, Kyle Bittinger and 3 more

Abstract read
In one paragraph

Article in mBio, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Early-life colonization withScience (New York, N.Y.) · 2026
    Article
  2. Article
  3. Article
  4. Journal of bacteriology · 2026
    Article
  5. Pharmacological reduction of neutrophil infiltration reducesbioRxiv : the preprint server for biology · 2025
    Article
  6. Review
  7. Review
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Joshua Soto Ocaña *Division of Protective Immunity, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.ORCID 0000-0002-8898-6630
Elliot S Friedman *Division of Gastroenterology & Hepatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID 0000-0003-0050-4965
Orlaith KeenanDivision of Protective Immunity, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Nile U BayardDivision of Protective Immunity, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Eileen FordDivision of Gastroenterology, Hepatology and Nutrition, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Ceylan TanesDivision of Gastroenterology, Hepatology and Nutrition, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Matthew J MunnekeDepartment of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
William N BeaversDepartment of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.ORCID 0000-0002-0285-7775
Eric P SkaarDepartment of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.ORCID 0000-0001-5094-8105
Kyle BittingerDivision of Gastroenterology, Hepatology and Nutrition, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.ORCID 0000-0003-3472-5934
Babette S ZemelDivision of Gastroenterology, Hepatology and Nutrition, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Gary D WuDivision of Gastroenterology & Hepatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID 0000-0002-1829-8795
Joseph P ZackularDivision of Protective Immunity, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.ORCID 0000-0002-3228-3055

Funding

Phenotypic Diversity in COVID-19UL1TR001878 · NCATS · UNIVERSITY OF PENNSYLVANIA · PI FITZGERALD, GARRET A · 2016 to 2025
$102.4M
TRANSGENIC AND CHIMERIC MOUSE COREP30DK050306 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI REBECCA G WELLS · 1997 to 2026
$32.5M
Translational Analysis CoreP30DK058404 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RICHARD M. PEEK · 2002 to 2026
$29.9M
Infant Growth and Microbiome Study 2R01DK107565 · NIDDK · CHILDREN'S HOSP OF PHILADELPHIA · PI WU, GARY D., ZEMEL, BABETTE S · 2015 to 2019
$3.6M
Molecular interactions in the gut microbiota during early life colonization and perturbationR35GM138369 · NIGMS · CHILDREN'S HOSP OF PHILADELPHIA · PI Joseph Paul Zackular · 2020 to 2026
$2.7M
HHS | National Institutes of Health (NIH) R01DK107565HHS | National Institutes of Health (NIH) R01DK107565, P30DK050306HHS | NIH | National Institute of General Medical Sciences (NIGMS) R35GM138369NCATS NIH HHS UL1 TR001878NIDDK NIH HHS P30 DK050306NIDDK NIH HHS P30 DK058404NIDDK NIH HHS R01 DK107565NIGMS NIH HHS R35 GM138369
6 · The paper itself

Abstract

The gut microbiota plays a critical role in human health and disease. Microbial community assembly and succession early in life are influenced by numerous factors. In turn, assembly of this microbial community is known to influence the host, including immune system development, and has been linked to outcomes later in life. To date, the role of host-mediated nutritional immunity and metal availability in shaping microbial community assembly and succession early in life has not been explored in depth. Using a human infant cohort, we show that the metal-chelating protein calprotectin is highly abundant in infants. Taxa previously shown to be successful early colonizers of the infant gut, such as

Indexed as

Gastrointestinal MicrobiomeLeukocyte L1 Antigen ComplexMetalsBacteriaBreast FeedingFecesGastrointestinal TractHumansInfantInfant FormulaInfant, NewbornMicrobiotaLeukocyte L1 Antigen ComplexMetalsearly lifegut microbiomeheavy metalshuman microbiomemicrobial ecologyneonates

Identifiers

PMID39440978
PMCPMC11558993

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.